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Review

An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection

1
Evidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de la Sabana, Chía 140013, Colombia
2
Facultad de Medicina, Univesidad de La Sabana, Chía 140013, Colombia
*
Author to whom correspondence should be addressed.
Received: 7 May 2019 / Revised: 7 July 2019 / Accepted: 8 July 2019 / Published: 24 July 2019
(This article belongs to the Special Issue Antimicrobial Resistance in Gram-negative Bacteria)
Antimicrobial resistance to antibiotic treatment has significantly increased during recent years, causing this to become a worldwide public health problem. More than 70% of pathogenic bacteria are resistant to at least one of the currently used antibiotics. Polymyxin E (colistin) has recently been used as a “last line” therapy when treating Gram-negative multi-resistant bacteria. However, little is known about these molecules’ pharmacological use as they have been discontinued because of their high toxicity. Recent research has been focused on determining colistimethate sodium’s pharmacokinetic parameters to find the optimal dose for maintaining a suitable benefit–risk balance. This review has thus been aimed at describing the use of colistin on patients infected by multi-drug resistant bacteria and the importance of measuring this drug’s plasma levels in such patients. View Full-Text
Keywords: colistin; antimicrobial resistance; Gram-negative bacteria; therapeutic drug monitoring (TDM); multidrug-resistant (MDR); pandrug-resistant (PDR); extensive-drug resistant (XDR) colistin; antimicrobial resistance; Gram-negative bacteria; therapeutic drug monitoring (TDM); multidrug-resistant (MDR); pandrug-resistant (PDR); extensive-drug resistant (XDR)
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MDPI and ACS Style

Pacheco, T.; Bustos, R.-H.; González, D.; Garzón, V.; García, J.-C.; Ramírez, D. An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection. Antibiotics 2019, 8, 100. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030100

AMA Style

Pacheco T, Bustos R-H, González D, Garzón V, García J-C, Ramírez D. An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection. Antibiotics. 2019; 8(3):100. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030100

Chicago/Turabian Style

Pacheco, Tatiana, Rosa-Helena Bustos, Diana González, Vivian Garzón, Julio-Cesar García, and Daniela Ramírez. 2019. "An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection" Antibiotics 8, no. 3: 100. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030100

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