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Article

Antimicrobial Drug Interactions: Systematic Evaluation of Protein and Nucleic Acid Synthesis Inhibitors

Department of Chemistry and Biology Engineering, Faculty of Engineering and Natural Sciences, Uskudar University, Uskudar, Istanbul 34662, Turkey
Received: 25 June 2019 / Revised: 2 August 2019 / Accepted: 5 August 2019 / Published: 9 August 2019
Antimicrobial multidrug resistance and its transmission among strains are serious problems. Success rate is decreased and treatment options are narrowed due to increasing bacterial multidrug resistance. On the other hand, the need for long-term efforts to discover new antibiotics and difficulties finding new treatment protocols make this problem more complex. Combination therapy, especially with synergistic use of antimicrobials is a rational treatment option with huge benefits. Thus, screening antibiotic interactions is crucial for finding better treatment options. Clinicians currently use combinatorial antibiotic treatment as an effective treatment option. However, antibiotics can show synergistic or antagonistic interactions when used together. In our study, we aimed to investigate interactions of antibiotics with different mechanisms of action. Antibiotics, which act as protein synthesis inhibitors (P) and nucleic acid synthesis inhibitors (N) were used in our study. We tested 66 (PN), 15 (NN), and 55 (PP) drug pairs on the Escherichia coli strain. The Loewe additivity model was used and alpha scores were calculated for analysis of interactions of drug combinations. Drug interactions were categorized as synergistic or antagonistic. Accordingly, pairwise combinations of protein synthesis inhibitors (PP) showed stronger synergistic interactions than those of nucleic acid synthesis inhibitors (NN) and nucleic acid synthesis–protein synthesis inhibitors (PN). As a result, the importance of mechanisms of action of drugs is emphasized in the selection of synergistic drug combinations. View Full-Text
Keywords: antagonism; antibiotic interactions; synergy antagonism; antibiotic interactions; synergy
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MDPI and ACS Style

Yilancioglu, K. Antimicrobial Drug Interactions: Systematic Evaluation of Protein and Nucleic Acid Synthesis Inhibitors. Antibiotics 2019, 8, 114. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030114

AMA Style

Yilancioglu K. Antimicrobial Drug Interactions: Systematic Evaluation of Protein and Nucleic Acid Synthesis Inhibitors. Antibiotics. 2019; 8(3):114. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030114

Chicago/Turabian Style

Yilancioglu, Kaan. 2019. "Antimicrobial Drug Interactions: Systematic Evaluation of Protein and Nucleic Acid Synthesis Inhibitors" Antibiotics 8, no. 3: 114. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030114

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