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Review

Put a Bow on It: Knotted Antibiotics Take Center Stage

Department of Biochemistry, MaRS Discovery District, University of Toronto, 661 University Avenue, Toronto, ON M5G 1M1, Canada
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Author to whom correspondence should be addressed.
Received: 18 July 2019 / Revised: 6 August 2019 / Accepted: 9 August 2019 / Published: 11 August 2019
(This article belongs to the Special Issue Mechanism and Regulation of Antibiotic Synthesis in Streptomyces)
Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large class of natural products produced across all domains of life. The lasso peptides, a subclass of RiPPs with a lasso-like structure, are structurally and functionally unique compared to other known peptide antibiotics in that the linear peptide is literally “tied in a knot” during its post-translational maturation. This underexplored class of peptides brings chemical diversity and unique modes of action to the antibiotic space. To date, eight different lasso peptides have been shown to target three known molecular machines: RNA polymerase, the lipid II precursor in peptidoglycan biosynthesis, and the ClpC1 subunit of the Clp protease involved in protein homeostasis. Here, we discuss the current knowledge on lasso peptide biosynthesis as well as their antibiotic activity, molecular targets, and mechanisms of action. View Full-Text
Keywords: lasso peptides; ribosomally synthesized post translationally modified peptide (RiPP); antibiotic; target; mechanism of action lasso peptides; ribosomally synthesized post translationally modified peptide (RiPP); antibiotic; target; mechanism of action
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MDPI and ACS Style

Tan, S.; Moore, G.; Nodwell, J. Put a Bow on It: Knotted Antibiotics Take Center Stage. Antibiotics 2019, 8, 117. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030117

AMA Style

Tan S, Moore G, Nodwell J. Put a Bow on It: Knotted Antibiotics Take Center Stage. Antibiotics. 2019; 8(3):117. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030117

Chicago/Turabian Style

Tan, Stephanie, Gaelen Moore, and Justin Nodwell. 2019. "Put a Bow on It: Knotted Antibiotics Take Center Stage" Antibiotics 8, no. 3: 117. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030117

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