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Review

Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

1
Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus 21300, Terengganu, Malaysia
2
Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu 20400, Terengganu, Malaysia
3
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
*
Author to whom correspondence should be addressed.
Received: 29 June 2019 / Revised: 19 August 2019 / Accepted: 22 August 2019 / Published: 26 August 2019
(This article belongs to the Special Issue Staphylococci Antimicrobial Resistance)
Staphylococcus aureus is an important nosocomial pathogen and its multidrug resistant strains, particularly methicillin-resistant S. aureus (MRSA), poses a serious threat to public health due to its limited therapeutic options. The increasing MRSA resistance towards vancomycin, which is the current drug of last resort, gives a great challenge to the treatment and management of MRSA infections. While vancomycin resistance among Malaysian MRSA isolates has yet to be documented, a case of vancomycin resistant S. aureus has been reported in our neighboring country, Indonesia. In this review, we present the antimicrobial resistance profiles of S. aureus clinical isolates in Malaysia with data obtained from the Malaysian National Surveillance on Antimicrobial Resistance (NSAR) reports as well as various peer-reviewed published records spanning a period of nearly three decades (1990–2017). We also review the clonal types and characteristics of Malaysian S. aureus isolates, where hospital-associated (HA) MRSA isolates tend to carry staphylococcal cassette chromosome mec (SCCmec) type III and were of sequence type (ST)239, whereas community-associated (CA) isolates are mostly SCCmec type IV/V and ST30. More comprehensive surveillance data that include molecular epidemiological data would enable further in-depth understanding of Malaysian S. aureus isolates. View Full-Text
Keywords: Antimicrobial resistance; community-associated (CA); hospital-associated (HA); Staphylococcus aureus; macrolide-lincosamide-streptogramin B (MLSB); Malaysian clinical isolates; methicillin-resistance S. aureus (MRSA); methicillin-susceptible S. aureus (MSSA); staphylococcal cassette chromosome mec (SCCmec) type; sequence types (STs) Antimicrobial resistance; community-associated (CA); hospital-associated (HA); Staphylococcus aureus; macrolide-lincosamide-streptogramin B (MLSB); Malaysian clinical isolates; methicillin-resistance S. aureus (MRSA); methicillin-susceptible S. aureus (MSSA); staphylococcal cassette chromosome mec (SCCmec) type; sequence types (STs)
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MDPI and ACS Style

Che Hamzah, A.M.; Yeo, C.C.; Puah, S.M.; Chua, K.H.; Chew, C.H. Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017. Antibiotics 2019, 8, 128. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030128

AMA Style

Che Hamzah AM, Yeo CC, Puah SM, Chua KH, Chew CH. Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017. Antibiotics. 2019; 8(3):128. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030128

Chicago/Turabian Style

Che Hamzah, Ainal M.; Yeo, Chew C.; Puah, Suat M.; Chua, Kek H.; Chew, Ching H. 2019. "Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017" Antibiotics 8, no. 3: 128. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030128

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