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Brief Report

Reduced Incidence of Carbapenem-Resistant Klebsiella pneumoniae Infections in Cardiac Surgery Patients after Implementation of an Antimicrobial Stewardship Project

1
Dipartimento di Scienze della Salute (DISSAL), University of Genoa, 16132 Genoa, Italy
2
Clinica Malattie Infettive, Ospedale Policlinico San Martino—IRCCS, 16132 Genoa, Italy
3
Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate (DISC), University of Genoa, 16132 Genoa, Italy
4
Divisione di Cardiochirurgia, Ospedale Policlinico San Martino - IRCCS, 16132 Genoa, Italy
5
Department of Cardiac Surgery, Glenfield Hospital, University Hospitals of Leicester, Leicester LE3 3QP, UK
6
Unità di Microbiologia, Ospedale Policlinico San Martino—IRCCS, 16132 Genoa, Italy
*
Author to whom correspondence should be addressed.
Equal contributors.
Received: 13 August 2019 / Revised: 23 August 2019 / Accepted: 26 August 2019 / Published: 28 August 2019
Infections due to carbapenem-resistant Klebsiella pneumoniae (CR-Kp) are associated with increased mortality in cardiac surgery patients. In this short communication, we report on the changes in the incidence of CR-Kp colonization and CR-Kp infection in cardiac surgery patients from 2014 to 2018 in a teaching hospital in Italy, after the implementation of an antimicrobial stewardship project in 2014. During the study period, 2261 patients underwent open-heart surgery. Of them, 130 were found to be colonized by CR-Kp (5.7%) and 52 developed a postoperative CR-Kp infection (2.3%). The crude in-hospital mortality in patients with CR-Kp infections was 48% (25/52). The incidences of both CR-Kp colonization (incidence rate ratio (IRR) 0.82, 95% confidence intervals (CI) 0.78–0.86, p < 0.001) and CR-Kp infection (IRR 0.76, 95% CI 0.69–0.83, p < 0.001) considerably decreased over the study period. This encouraging result should prompt further concerted efforts, directed towards retaining the positive impact of stewardship and infection-control interventions on CR-Kp-related morbidity in the long term. View Full-Text
Keywords: Klebsiella; stewardship; postoperative infections Klebsiella; stewardship; postoperative infections
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MDPI and ACS Style

Giacobbe, D.R.; Salsano, A.; Puente, F.D.; Campanini, F.; Mariscalco, G.; Marchese, A.; Viscoli, C.; Santini, F. Reduced Incidence of Carbapenem-Resistant Klebsiella pneumoniae Infections in Cardiac Surgery Patients after Implementation of an Antimicrobial Stewardship Project. Antibiotics 2019, 8, 132. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030132

AMA Style

Giacobbe DR, Salsano A, Puente FD, Campanini F, Mariscalco G, Marchese A, Viscoli C, Santini F. Reduced Incidence of Carbapenem-Resistant Klebsiella pneumoniae Infections in Cardiac Surgery Patients after Implementation of an Antimicrobial Stewardship Project. Antibiotics. 2019; 8(3):132. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030132

Chicago/Turabian Style

Giacobbe, Daniele Roberto; Salsano, Antonio; Puente, Filippo Del; Campanini, Francesco; Mariscalco, Giovanni; Marchese, Anna; Viscoli, Claudio; Santini, Francesco. 2019. "Reduced Incidence of Carbapenem-Resistant Klebsiella pneumoniae Infections in Cardiac Surgery Patients after Implementation of an Antimicrobial Stewardship Project" Antibiotics 8, no. 3: 132. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030132

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