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Article

Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains

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Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
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Instituto de Bioengenharia e Biociências, Departamento de Bioengenharia, Instituto Superior Técnico Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
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Centro de Química-Física Molecular e BSIRG, Instituto de Bioengenharia e Biociências, Instituto Superior Técnico Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
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C2TN Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS, Portugal
*
Authors to whom correspondence should be addressed.
Received: 22 August 2019 / Revised: 6 September 2019 / Accepted: 9 September 2019 / Published: 10 September 2019
(This article belongs to the Special Issue Feature Paper in Antibiotics for 2019)
Hydroxide [Ag(OH)L] (L = IVL, VL, VIL, VIIL), oxide [{AgL}2}(μ-O)] (L = IL, IIL, IIIL, VL, VIL) or chloride [AgIIL]Cl, [Ag(VIL)2]Cl complexes were obtained from reactions of mono- or bicamphorimine derivatives with Ag(OAc) or AgCl. The new complexes were characterized by spectroscopic (NMR, FTIR) and elemental analysis. X-ray photoelectron spectroscopy (XPS), ESI mass spectra and conductivity measurements were undertaken to corroborate formulations. The antimicrobial activity of complexes and some ligands were evaluated towards Candida albicans and Candida glabrata, and strains of the bacterial species Escherichia coli, Burkholderia contaminans, Pseudomonas aeruginosa and Staphylococcus aureus based on the Minimum Inhibitory Concentrations (MIC). Complexes displayed very high activity against the Candida species studied with the lowest MIC values (3.9 µg/mL) being observed for complexes 9 and 10A against C. albicans. A significant feature of these redesigned complexes is their ability to sensitize C. albicans, a trait that was not found for the previously investigated [Ag(NO3)L] complexes. The MIC values of the complexes towards bacteria were in the range of those of [Ag(NO3)L] and well above those of the precursors Ag(OAc) or AgCl. The activity of the complexes towards normal fibroblasts V79 was evaluated by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. Results showed that the complexes have a significant cytotoxicity. View Full-Text
Keywords: silver complexes; camphorimine; anti-Candida activity; antifungals; antibacterials silver complexes; camphorimine; anti-Candida activity; antifungals; antibacterials
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MDPI and ACS Style

Costa, J.P.; Pinheiro, M.J.F.; Sousa, S.A.; Botelho do Rego, A.M.; Marques, F.; Oliveira, M.C.; Leitão, J.H.; P. Mira, N.; N. N. Carvalho, M.F. Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains. Antibiotics 2019, 8, 144. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030144

AMA Style

Costa JP, Pinheiro MJF, Sousa SA, Botelho do Rego AM, Marques F, Oliveira MC, Leitão JH, P. Mira N, N. N. Carvalho MF. Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains. Antibiotics. 2019; 8(3):144. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030144

Chicago/Turabian Style

Costa, Joana P., M. J.F. Pinheiro, Sílvia A. Sousa, Ana M. Botelho do Rego, Fernanda Marques, M. C. Oliveira, Jorge H. Leitão, Nuno P. Mira, and M. F. N. N. Carvalho 2019. "Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains" Antibiotics 8, no. 3: 144. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030144

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