Next Article in Journal
Global Internet Data on the Interest in Antibiotics and Probiotics Generated by Google Trends
Next Article in Special Issue
Carbapenem-Resistant Enterobacteriaceae Posing a Dilemma in Effective Healthcare Delivery
Previous Article in Journal
Structural Analysis of The OXA-48 Carbapenemase Bound to A “Poor” Carbapenem Substrate, Doripenem
Previous Article in Special Issue
Longitudinal Shedding Patterns and Characterization of Antibiotic Resistant E. coli in Pastured Goats Using a Cohort Study
Communication

Carbapenemase-Producing Elizabethkingia Meningoseptica from Healthy Pigs Associated with Colistin Use in Spain

1
VISAVET Health Surveillance Centre, Universidad Complutense, Madrid 28040, Spain
2
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain
3
Laboratorio de Biología Molecular y Microbiología, Instituto Tecnológico Agrario de Castilla y León, 47071 Valladolid, Spain
4
Área de Microbiología, Departamento de Biotecnología y Ciencia de los Alimentos, Universidad de Burgos, 09001 Burgos, Spain
5
Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, 10003 Cáceres, Spain
6
INBIO G+C, Universidad de Extremadura, 10003 Cáceres, Spain
*
Author to whom correspondence should be addressed.
Received: 20 August 2019 / Revised: 5 September 2019 / Accepted: 6 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue Antimicrobial Resistance in Gram-negative Bacteria)
Carbapenems are considered last-resort antimicrobials, especially for treating infections involving multidrug-resistant Gram-negative bacteria. In recent years, extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Gram-negative bacteria have become widespread in hospitals, community settings, and the environment, reducing the range of effective therapeutic alternatives. The use of colistin to treat infection caused by these multi-drug bacteria may favour the selection and persistence of carbapenem-resistant bacteria. In this study, it is described, for the first time to our knowledge, a carbapenemase-producing isolate of Elizabethkingia meningoseptica from healthy pigs in Spain. The isolate we report was recovered during a study to detect colistin-resistant bacteria from faecal samples of healthy food-production animals using a chromogenic selective medium. Unexpectedly, we found an isolate of Elizabethkingia meningoseptica with high Minimum Inhibitory Concentration (MIC) values for several antibiotics tested. Molecular analysis did not show any mcr family genes related with colistin resistance, but two carbapenemase genes, blaB-12_1 and blaGOB-17_1, were detected. This finding in healthy animals could suggest that colistin may favour the selection and persistence of carbapenem-resistant bacteria. View Full-Text
Keywords: carbapenemase; colistin; Elizabethkingia meningoseptica; Antimicrobial resistance carbapenemase; colistin; Elizabethkingia meningoseptica; Antimicrobial resistance
MDPI and ACS Style

Miguela-Villoldo, P.; Hernández, M.; Moreno, M.Á.; Rodríguez-Lázaro, D.; Quesada, A.; Domínguez, L.; Ugarte-Ruiz, M. Carbapenemase-Producing Elizabethkingia Meningoseptica from Healthy Pigs Associated with Colistin Use in Spain. Antibiotics 2019, 8, 146. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030146

AMA Style

Miguela-Villoldo P, Hernández M, Moreno MÁ, Rodríguez-Lázaro D, Quesada A, Domínguez L, Ugarte-Ruiz M. Carbapenemase-Producing Elizabethkingia Meningoseptica from Healthy Pigs Associated with Colistin Use in Spain. Antibiotics. 2019; 8(3):146. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030146

Chicago/Turabian Style

Miguela-Villoldo, Pedro; Hernández, Marta; Moreno, Miguel Á.; Rodríguez-Lázaro, David; Quesada, Alberto; Domínguez, Lucas; Ugarte-Ruiz, María. 2019. "Carbapenemase-Producing Elizabethkingia Meningoseptica from Healthy Pigs Associated with Colistin Use in Spain" Antibiotics 8, no. 3: 146. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030146

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop