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Case Report

Pseudomonas aeruginosa Coharboring BlaKPC-2 and BlaVIM-2 Carbapenemase Genes

1
Grupo Evidencia Terapéutica, Clinical Pharmacology, Universidad de la Sabana, Chía 140013, Colombia
2
Laboratorio de Genética Molecular Bacteriana, Universidad El Bosque, Bogotá 111321, Colombia
*
Author to whom correspondence should be addressed.
Received: 15 March 2019 / Revised: 11 May 2019 / Accepted: 18 May 2019 / Published: 20 July 2019
(This article belongs to the Special Issue Antimicrobial Resistance in Gram-negative Bacteria)
Pseudomonas aeruginosa, a bacterium commonly isolated from hospital settings, exhibits intrinsic resistance to a number of antibiotics and can acquire resistance during antibiotic therapy. Resistance towards carbapenems is increasing due to its overuse in the treatment of infections caused by extended-spectrum β-lactamase (ESBL) producing organisms. Nonetheless, carbapenems are essential for the treatment of high-risk infections and are one of the remaining weapons in the fight against “extreme drug resistance” of Gram-negative/positive bacilli. Herein, we describe a case report of infections caused by P. aeruginosa strains that carry blaVIM-2 and blaKPC-2 carbapenemase genes simultaneously, identified in five patients who were admitted to a high complexity health institution in Colombia. Molecular characterization included PCR screening for blaKPC, blaGES, blaOXA-48, blaIMP, blaNDM, and blaVIM carbapenemase and other resistance genes as well as analysis of the genetic relationships by genome macro-restriction and Pulsed-Field Gel Electrophoresis (PFGE) separation. In conclusion, these infections represent a major challenge to public health due to the risk of the infection spreading compounded by the fact that limited treatment options are available, thereby increasing the risk of increased morbidity and mortality. View Full-Text
Keywords: Pseudomonas aeruginosa; carbapenems; carbapenemases; Verona Integron-encoded metallo-β-lactamase (VIM); Klebsiella pneumoniae carbepenemase (KPC); drug resistance Pseudomonas aeruginosa; carbapenems; carbapenemases; Verona Integron-encoded metallo-β-lactamase (VIM); Klebsiella pneumoniae carbepenemase (KPC); drug resistance
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MDPI and ACS Style

Pacheco, T.; Bustos-Cruz, R.H.; Abril, D.; Arias, S.; Uribe, L.; Rincón, J.; García, J.-C.; Escobar-Perez, J. Pseudomonas aeruginosa Coharboring BlaKPC-2 and BlaVIM-2 Carbapenemase Genes. Antibiotics 2019, 8, 98. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030098

AMA Style

Pacheco T, Bustos-Cruz RH, Abril D, Arias S, Uribe L, Rincón J, García J-C, Escobar-Perez J. Pseudomonas aeruginosa Coharboring BlaKPC-2 and BlaVIM-2 Carbapenemase Genes. Antibiotics. 2019; 8(3):98. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030098

Chicago/Turabian Style

Pacheco, Tatiana, Rosa H. Bustos-Cruz, Deisy Abril, Sara Arias, Lina Uribe, Jenny Rincón, Julio-Cesar García, and Javier Escobar-Perez. 2019. "Pseudomonas aeruginosa Coharboring BlaKPC-2 and BlaVIM-2 Carbapenemase Genes" Antibiotics 8, no. 3: 98. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8030098

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