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Review

Host-Targeted Therapeutics against Multidrug Resistant Intracellular Staphylococcus aureus

1
Health Sciences Research Centre, University of Roehampton, London SW15 4JD, UK
2
Department of Molecular Biology, Area of Microbiology, University of León, 24004 León, Spain
*
Author to whom correspondence should be addressed.
Received: 29 October 2019 / Revised: 21 November 2019 / Accepted: 25 November 2019 / Published: 28 November 2019
(This article belongs to the Special Issue Novel Strategies against Pathogenic Bacteria)
Staphylococcus aureus is a facultative intracellular pathogen that invades and replicates within many types of human cells. S. aureus has shown to rapidly overcome traditional antibiotherapy by developing multidrug resistance. Furthermore, intracellular S. aureus is protected from the last-resort antibiotics—vancomycin, daptomycin, and linezolid—as they are unable to achieve plasma concentrations sufficient for intracellular killing. Therefore, there is an urgent need to develop novel anti-infective therapies against S. aureus infections. Here, we review the current state of the field and highlight the exploitation of host-directed approaches as a promising strategy going forward. View Full-Text
Keywords: Staphylococcus aureus; host-targeted; repurposing drugs; intracellular pathogen Staphylococcus aureus; host-targeted; repurposing drugs; intracellular pathogen
MDPI and ACS Style

Bravo-Santano, N.; Behrends, V.; Letek, M. Host-Targeted Therapeutics against Multidrug Resistant Intracellular Staphylococcus aureus. Antibiotics 2019, 8, 241. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8040241

AMA Style

Bravo-Santano N, Behrends V, Letek M. Host-Targeted Therapeutics against Multidrug Resistant Intracellular Staphylococcus aureus. Antibiotics. 2019; 8(4):241. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8040241

Chicago/Turabian Style

Bravo-Santano, Natalia, Volker Behrends, and Michal Letek. 2019. "Host-Targeted Therapeutics against Multidrug Resistant Intracellular Staphylococcus aureus" Antibiotics 8, no. 4: 241. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8040241

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