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Article

Essential Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria

1
Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil
2
Gonçalo Moniz Institute, Fundação Oswaldo Cruz (IGM-FIOCRUZ/BA), Salvador 40296-710, Brazil
3
Setor Litoral, Federal University of Paraná, Curitiba 80060-000, Brazil
4
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Received: 6 December 2019 / Revised: 7 January 2020 / Accepted: 10 January 2020 / Published: 14 January 2020
(This article belongs to the Special Issue Antimicrobial Plant Extracts and Phytochemicals)
This study is a pioneer in reporting the antibacterial properties of the species Croton ceanothifolius Baill. The genus Croton belongs to the family Euphorbiaceae composed of numerous species with documented biological activities. However, the pharmacological properties of C. ceanothifolius remain poorly understood. The leaves of this plant were submitted to hydrodistillation for essential oil (CcEO) extraction and the phytochemical characterization of the oil was performed by GC/MS. The minimum inhibitory concentration of the CcEO was determined for the evaluation of antibacterial activity against multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. The antibiotic-modulating activity of the oil, in combination with antibiotics, was also evaluated. The combination of the CcEO with penicillin, norfloxacin, and gentamicin presented a synergistic effect. This effect was more significant for the association with antibiotics of the quinolone and aminoglycoside classes against Escherichia coli. The association of oil with gentamicin showed better results with regard to the Gram-positive strain. The association of the oil with norfloxacin against P. aeruginosa also showed synergism, but the association with penicillin did not change the effect of this antibiotic. Thus, it is concluded that C. ceanothifolius essential oil selectively potentiates the action of antibiotics against multiresistant strains. View Full-Text
Keywords: antibiotics; bacterial resistance; Croton ceanothifolius; essential oils antibiotics; bacterial resistance; Croton ceanothifolius; essential oils
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MDPI and ACS Style

J. de Araújo, A.C.; R. Freitas, P.; Rodrigues dos Santos Barbosa, C.; Muniz, D.F.; Esmeraldo Rocha, J.; Neto, J.B.d.A.; C. da Silva, M.M.; Moura, T.F.; Pereira, R.L.S.; Ribeiro-Filho, J.; Silva, L.E.d.; do Amaral, W.; Deschamps, C.; Tintino, S.R.; Iriti, M.; Vitalini, S.; Melo Coutinho, H.D. Essential Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria. Antibiotics 2020, 9, 27. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9010027

AMA Style

J. de Araújo AC, R. Freitas P, Rodrigues dos Santos Barbosa C, Muniz DF, Esmeraldo Rocha J, Neto JBdA, C. da Silva MM, Moura TF, Pereira RLS, Ribeiro-Filho J, Silva LEd, do Amaral W, Deschamps C, Tintino SR, Iriti M, Vitalini S, Melo Coutinho HD. Essential Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria. Antibiotics. 2020; 9(1):27. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9010027

Chicago/Turabian Style

J. de Araújo, Ana C., Priscilla R. Freitas, Cristina Rodrigues dos Santos Barbosa, Débora F. Muniz, Janaína Esmeraldo Rocha, José B.d.A. Neto, Maria M. C. da Silva, Talysson F. Moura, Raimundo L.S. Pereira, Jaime Ribeiro-Filho, Luiz E.d. Silva, Wanderlei do Amaral, Cícero Deschamps, Saulo R. Tintino, Marcello Iriti, Sara Vitalini, and Henrique D. Melo Coutinho 2020. "Essential Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria" Antibiotics 9, no. 1: 27. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9010027

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