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Chemical Composition and Antibacterial Activity of Essential Oils from the Algerian Endemic Origanum glandulosum Desf. against Multidrug-Resistant Uropathogenic E. coli Isolates

1
Laboratoire de Valorisation des Ressources Biologiques Naturelles (LVRBN), Université de Sétif 1, Sétif 19000, Algeria
2
Département des Sciences Naturelles, École Normale Supérieure Assia DJEBAR, Constantine 25000, Algeria
3
Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University Sokoto, Sokoto 840244, Nigeria
4
School of Pharmacy, University of Camerino, 62032 Camerino, Italy
*
Authors to whom correspondence should be addressed.
Received: 3 December 2019 / Revised: 10 January 2020 / Accepted: 12 January 2020 / Published: 15 January 2020
(This article belongs to the Special Issue Antibacterial Activity of Plant Extracts and Essential Oils)
Antibiotics are becoming ineffective against resistant bacteria. The use of essential oils (EOs) may constitute an alternative solution to fight against multidrug-resistant bacteria. This study aims to determine the chemical composition of EOs from five populations of the endemic Algerian Origanum glandulosum Desf. and to investigate their potential antibacterial activity against multidrug-resistant uropathogenic E. coli strains. The EOs were obtained by hydrodistillation and their composition was investigated by gas chromatography/mass spectrometry (GC/MS). The antibacterial activity was evaluated by the disc diffusion method against eight E. coli strains (six uropathogenic resistant and two referenced susceptible strains). Minimum inhibitory and bactericidal concentrations (MIC/MBC) were obtained by the broth microdilution method. The main EO components were thymol (15.2–56.4%), carvacrol (2.8–59.6%), γ-terpinene (9.9–21.8%) and p-cymene (8.5–13.9%). The antibacterial tests showed that all the EOs were active against all the strains, including the multidrug-resistant strains. The EO from the Bordj location, which contained the highest amount of carvacrol (59.6%), showed the highest antibacterial activity (inhibition diameters from 12 to 24.5 mm at a dilution of 1/10). To our knowledge, this is the first description of the activity of O. glandulosum EOs against resistant uropathogenic strains. Our study suggests that O. glandulosum EO could be used in some clinical situations to treat or prevent infections (e.g., urinary tract infections) with multidrug-resistant strains. View Full-Text
Keywords: multidrug-resistant E. coli; Origanum glandulosum Desf.; essential oil; GC-MS; antibacterial activity multidrug-resistant E. coli; Origanum glandulosum Desf.; essential oil; GC-MS; antibacterial activity
MDPI and ACS Style

Zakaria Nabti, L.; Sahli, F.; Laouar, H.; Olowo-okere, A.; Nkuimi Wandjou, J.G.; Maggi, F. Chemical Composition and Antibacterial Activity of Essential Oils from the Algerian Endemic Origanum glandulosum Desf. against Multidrug-Resistant Uropathogenic E. coli Isolates. Antibiotics 2020, 9, 29. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9010029

AMA Style

Zakaria Nabti L, Sahli F, Laouar H, Olowo-okere A, Nkuimi Wandjou JG, Maggi F. Chemical Composition and Antibacterial Activity of Essential Oils from the Algerian Endemic Origanum glandulosum Desf. against Multidrug-Resistant Uropathogenic E. coli Isolates. Antibiotics. 2020; 9(1):29. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9010029

Chicago/Turabian Style

Zakaria Nabti, Larbi, Farida Sahli, Hocine Laouar, Ahmed Olowo-okere, Joice G. Nkuimi Wandjou, and Filippo Maggi. 2020. "Chemical Composition and Antibacterial Activity of Essential Oils from the Algerian Endemic Origanum glandulosum Desf. against Multidrug-Resistant Uropathogenic E. coli Isolates" Antibiotics 9, no. 1: 29. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9010029

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