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Article

A Pilot Study in Sweden on Efficacy of Benzylpenicillin, Oxytetracycline, and Florfenicol in Treatment of Acute Undifferentiated Respiratory Disease in Calves

1
Farm and Animal Health, Kungsängens Gård, SE-753 23 Uppsala, Sweden
2
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, SE-750 07 Uppsala, Sweden
3
Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, SE-751 89 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Received: 29 September 2020 / Revised: 22 October 2020 / Accepted: 25 October 2020 / Published: 26 October 2020
Bovine respiratory disease (BRD) is a major indication for antibiotic treatment of cattle worldwide and some of the antibiotics used belong to classes of highest priority among those listed by WHO as critically important for human medicine. To preserve the efficacy of “newer” antibiotics, it has been suggested that “older” drugs should be revisited and used when possible. In this pilot study, we evaluated the efficacy of benzylpenicillin (PEN), oxytetracycline (OTC), and florfenicol (FLO) for treatment of naturally occurring BRD on two farms raising calves for slaughter. Farm personnel selected calves for enrolment, assigned calves to one of the three regimens in a systematically random manner, treated the calves, and registered the results. Overall, 117 calves were enrolled in the study. Nineteen calves relapsed in BRD before slaughter and were retreated (16.2%) and three died (2.6%). For PEN, treatment response rates after 30 days, 60 days, and until slaughter were 90.2%, 87.8%, and 80.5%, respectively; for OTC, 90.0%, 85.0%, and 85.0%, respectively; and for FLO, 86.1%, 83.3%, and 77.8%, respectively. There were no statistically significant differences in relapse, mortality, or response rates between the three treatment regimens. This indicates that PEN, OTC, and FLO were equally effective for treatment of BRD but the results need to be confirmed in a more elaborate study with a higher statistical power. The findings support the current recommendations from the Swedish Veterinary Association and the Medical Products Agency to use benzylpenicillin as a first line antibiotic for treatment of calves with undifferentiated respiratory disease in Sweden. Due to differences in the panorama of infectious agents and presence of acquired antibiotic resistance, the findings might not be applicable in other geographical areas. View Full-Text
Keywords: cattle; respiratory disease; treatment; benzylpenicillin; oxytetracycline; florfenicol cattle; respiratory disease; treatment; benzylpenicillin; oxytetracycline; florfenicol
MDPI and ACS Style

Welling, V.; Lundeheim, N.; Bengtsson, B. A Pilot Study in Sweden on Efficacy of Benzylpenicillin, Oxytetracycline, and Florfenicol in Treatment of Acute Undifferentiated Respiratory Disease in Calves. Antibiotics 2020, 9, 736. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9110736

AMA Style

Welling V, Lundeheim N, Bengtsson B. A Pilot Study in Sweden on Efficacy of Benzylpenicillin, Oxytetracycline, and Florfenicol in Treatment of Acute Undifferentiated Respiratory Disease in Calves. Antibiotics. 2020; 9(11):736. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9110736

Chicago/Turabian Style

Welling, Virpi, Nils Lundeheim, and Björn Bengtsson. 2020. "A Pilot Study in Sweden on Efficacy of Benzylpenicillin, Oxytetracycline, and Florfenicol in Treatment of Acute Undifferentiated Respiratory Disease in Calves" Antibiotics 9, no. 11: 736. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9110736

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