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Article

Poly-ε-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis

1
Department of Drugs and Medicines, School of Pharmaceutical Sciences, School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara-Jaú, Km 1, Araraquara, SP 14800-903, Brazil
2
Department of Mycology, Lauro de Souza Lima Institute, Bauru, SP 17034-971, Brazil
3
Department of Pharmacy, School of Pharmacy, Dentistry and Nursing, Federal University of Ceará, University Avenue, 2853 Rodolfo Teófilo, Fortaleza, CE 60430160, Brazil
4
School of Chemical and Pharmaceutical Sciences, University of Chile, Santos Dumont 964, Independencia, Santiago 8380492, Chile
5
Advanced Center for Chronic Diseases, Sergio Livingstone 1007, Santiago 8380492, Chile
*
Author to whom correspondence should be addressed.
Received: 1 November 2020 / Revised: 3 December 2020 / Accepted: 6 December 2020 / Published: 11 December 2020
Dermatophyte fungal infections are difficult to treat because they need long-term treatments. 4-Nerolidylcatechol (4-NC) is a compound found in Piper umbellatum that has been reported to demonstrate significant antifungal activity, but is easily oxidizable. Due to this characteristic, the incorporation in nanostructured systems represents a strategy to guarantee the compound’s stability compared to the isolated form and the possibility of improving antifungal activity. The objective of this study was to incorporate 4-NC into polymeric nanoparticles to evaluate, in vitro and in vivo, the growth inhibition of Microsporum canis. 4-NC was isolated from fresh leaves of P. umbellatum, and polymer nanoparticles of polycaprolactone were developed by nanoprecipitation using a 1:5 weight ratio (drug:polymer). Nanoparticles exhibited excellent encapsulation efficiency, and the antifungal activity was observed in nanoparticles with 4-NC incorporated. Polymeric nanoparticles can be a strategy employed for decreased cytotoxicity, increasing the stability and solubility of substances, as well as improving the efficacy of 4-NC. View Full-Text
Keywords: nanoparticles; 4-Nerolidylcatechol; antifungals; Microsporum canis; polycaprolactone; nanoprecipitation nanoparticles; 4-Nerolidylcatechol; antifungals; Microsporum canis; polycaprolactone; nanoprecipitation
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MDPI and ACS Style

Greatti, V.R.; Oda, F.; Sorrechia, R.; Kapp, B.R.; Seraphim, C.M.; Weckwerth, A.C.V.B.; Chorilli, M.; Silva, P.B.D.; Eloy, J.O.; Kogan, M.J.; Morales, J.O.; Pietro, R.C.L.R. Poly-ε-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis. Antibiotics 2020, 9, 894. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9120894

AMA Style

Greatti VR, Oda F, Sorrechia R, Kapp BR, Seraphim CM, Weckwerth ACVB, Chorilli M, Silva PBD, Eloy JO, Kogan MJ, Morales JO, Pietro RCLR. Poly-ε-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis. Antibiotics. 2020; 9(12):894. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9120894

Chicago/Turabian Style

Greatti, Vanessa R., Fernando Oda, Rodrigo Sorrechia, Bárbara R. Kapp, Carolina M. Seraphim, Ana C.V.B. Weckwerth, Marlus Chorilli, Patrícia B.D. Silva, Josimar O. Eloy, Marcelo J. Kogan, Javier O. Morales, and Rosemeire C.L.R. Pietro 2020. "Poly-ε-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis" Antibiotics 9, no. 12: 894. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9120894

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