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Review

Anti-Fungal Efficacy and Mechanisms of Flavonoids

Department of Biology, College of Science, Al-Zulfi, Majmaah University, Riyadh Region, Majmaah 11952, Saudi Arabia
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Author to whom correspondence should be addressed.
Received: 31 December 2019 / Revised: 11 January 2020 / Accepted: 13 January 2020 / Published: 26 January 2020
(This article belongs to the Special Issue Antimicrobial Plant Extracts and Phytochemicals)
The prevalence of fungal infections is growing at an alarming pace and the pathogenesis is still not clearly understood. Recurrence of these fungal diseases is often due to their evolutionary avoidance of antifungal resistance. The development of suitable novel antimicrobial agents for fungal diseases continues to be a major problem in the current clinical field. Hence, it is urgently necessary to develop surrogate agents that are more effective than conventional available drugs. Among the remarkable innovations from earlier investigations on natural-drugs, flavonoids are a group of plant-derived substances capable of promoting many valuable effects on humans. The identification of flavonoids with possible antifungal effects at small concentrations or in synergistic combinations could help to overcome this problem. A combination of flavonoids with available drugs is an excellent approach to reduce the side effects and toxicity. This review focuses on various naturally occurring flavonoids and their antifungal activities, modes of action, and synergetic use in combination with conventional drugs. View Full-Text
Keywords: flavonoids; fungal diseases; mode of action; antifungal activity flavonoids; fungal diseases; mode of action; antifungal activity
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MDPI and ACS Style

Al Aboody, M.S.; Mickymaray, S. Anti-Fungal Efficacy and Mechanisms of Flavonoids. Antibiotics 2020, 9, 45. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9020045

AMA Style

Al Aboody MS, Mickymaray S. Anti-Fungal Efficacy and Mechanisms of Flavonoids. Antibiotics. 2020; 9(2):45. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9020045

Chicago/Turabian Style

Al Aboody, Mohammed S., and Suresh Mickymaray. 2020. "Anti-Fungal Efficacy and Mechanisms of Flavonoids" Antibiotics 9, no. 2: 45. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9020045

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