Next Article in Journal
Antibiotic Resistance and Therapy Outcome in H. pylori Eradication Failure Patients
Next Article in Special Issue
The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria
Previous Article in Journal
Antibiotic Resistance in Marine Microbial Communities Proximal to a Florida Sewage Outfall System
Previous Article in Special Issue
Synthesis and Bioactivity of Thiazolethioacetamides as Potential Metallo-β-Lactamase Inhibitors
Open AccessReview

Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen

1
College of Natural and Health Sciences, Zayed University, Dubai P.O. Box 144534, UAE
2
Department of Pharmaceutical Sciences, School of Pharmacy, Lebanese International University, Beirut, Bekaa Campuses 1103, Lebanon
*
Author to whom correspondence should be addressed.
Authors contributed equally to the manuscript.
Received: 3 February 2020 / Revised: 1 March 2020 / Accepted: 2 March 2020 / Published: 12 March 2020
Being a multidrug-resistant and an invasive pathogen, Acinetobacter baumannii is one of the major causes of nosocomial infections in the current healthcare system. It has been recognized as an agent of pneumonia, septicemia, meningitis, urinary tract and wound infections, and is associated with high mortality. Pathogenesis in A. baumannii infections is an outcome of multiple virulence factors, including porins, capsules, and cell wall lipopolysaccharide, enzymes, biofilm production, motility, and iron-acquisition systems, among others. Such virulence factors help the organism to resist stressful environmental conditions and enable development of severe infections. Parallel to increased prevalence of infections caused by A. baumannii, challenging and diverse resistance mechanisms in this pathogen are well recognized, with major classes of antibiotics becoming minimally effective. Through a wide array of antibiotic-hydrolyzing enzymes, efflux pump changes, impermeability, and antibiotic target mutations, A. baumannii models a unique ability to maintain a multidrug-resistant phenotype, further complicating treatment. Understanding mechanisms behind diseases, virulence, and resistance acquisition are central to infectious disease knowledge about A. baumannii. The aims of this review are to highlight infections and disease-producing factors in A. baumannii and to touch base on mechanisms of resistance to various antibiotic classes. View Full-Text
Keywords: Acinetobacter baumannii; multidrug resistance; virulence factors; antibiotics; pathogenesis Acinetobacter baumannii; multidrug resistance; virulence factors; antibiotics; pathogenesis
Show Figures

Figure 1

MDPI and ACS Style

Ayoub Moubareck, C.; Hammoudi Halat, D. Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen. Antibiotics 2020, 9, 119. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9030119

AMA Style

Ayoub Moubareck C, Hammoudi Halat D. Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen. Antibiotics. 2020; 9(3):119. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9030119

Chicago/Turabian Style

Ayoub Moubareck, Carole; Hammoudi Halat, Dalal. 2020. "Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen" Antibiotics 9, no. 3: 119. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9030119

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop