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Open AccessReview

Bacteriophage Therapy: Developments and Directions

Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
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Author to whom correspondence should be addressed.
Received: 13 February 2020 / Revised: 17 March 2020 / Accepted: 18 March 2020 / Published: 24 March 2020
(This article belongs to the Special Issue Nontraditional Antibiotics—Challenges and Triumphs)
In an era of proliferating multidrug resistant bacterial infections that are exhausting the capacity of existing chemical antibiotics and in which the development of new antibiotics is significantly rarer, Western medicine must seek additional therapeutic options that can be employed to treat these infections. Among the potential antibacterial solutions are bacteriophage therapeutics, which possess very different properties from broad spectrum antibiotics that are currently the standard of care, and which can be used in combination with them and often provide synergies. In this review we summarize the state of the development of bacteriophage therapeutics and discuss potential paths to the implementation of phage therapies in contemporary medicine, focused on fixed phage cocktail therapeutics since these are likely to be the first bacteriophage products licensed for broad use in Western countries. View Full-Text
Keywords: bacteriophage therapy; antimicrobial; multidrug resistance; phage cocktail bacteriophage therapy; antimicrobial; multidrug resistance; phage cocktail
MDPI and ACS Style

Nikolich, M.P.; Filippov, A.A. Bacteriophage Therapy: Developments and Directions. Antibiotics 2020, 9, 135. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9030135

AMA Style

Nikolich MP, Filippov AA. Bacteriophage Therapy: Developments and Directions. Antibiotics. 2020; 9(3):135. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9030135

Chicago/Turabian Style

Nikolich, Mikeljon P.; Filippov, Andrey A. 2020. "Bacteriophage Therapy: Developments and Directions" Antibiotics 9, no. 3: 135. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9030135

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