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Article

Essential Oils of Aromatic Plants with Antibacterial, Anti-Biofilm and Anti-Quorum Sensing Activities against Pathogenic Bacteria

1
Escuela de Medicina, Universidad Industrial de Santander, Bucaramanga 680002, Colombia
2
Escuela de Química, Universidad Industrial de Santander, Bucaramanga 680002, Colombia
3
Laboratorio de Biotecnología CEO, Instituto Colombiano del Petróleo, ECOPETROL, Piedecuesta 681012, Santander, Colombia
4
Escuela de Microbiología y Bioanálisis, Universidad Industrial de Santander, Bucaramanga 680002, Colombia
*
Author to whom correspondence should be addressed.
Received: 6 February 2020 / Revised: 28 February 2020 / Accepted: 1 March 2020 / Published: 30 March 2020
(This article belongs to the Special Issue Synthesis and Pharmacokinetics of Antibiotics)
Both the ability of bacteria to form biofilms and communicate through quorum sensing allows them to develop different survival or virulence traits that lead to increased bacterial resistance against conventional antibiotic therapy. Here, seventeen essential oils (EOs) were investigated for the antimicrobial, antibiofilm, and anti-quorum sensing activities on Escherichia. coli O157:H7, Escherichia coli O33, and Staphylococcus epidermidis ATCC 12228. All essential oils were isolated from plant material by using hydrodistillation and analyzed by GC-MS. The antimicrobial activity was performed by using the microdilution technique. Subinhibitory concentrations of each EO were assayed for biofilm inhibition in both bacterial strains. Quantification of violacein in Chromobacterium violaceum CV026 was performed for the anti-quorum sensing activity. The cytotoxicity activity of the EOs was evaluated on Vero cell line by using MTT method. Thymol-carvacrol-chemotype (I and II) oils from Lippia origanoides and Thymus vulgaris oil exhibited the higher antimicrobial activity with MIC values of 0.37–0.75 mg/mL. In addition, these EOs strongly inhibited the biofilm formation and violacein (QS) production in a concentration-dependent manner, highlighting thymol-carvacrol-chemotype (II) oil as the best candidate for further studies in antibiotic design and development against bacterial resistance. View Full-Text
Keywords: Essential oil; pathogenic bacteria; biofilm; quorum sensing; microbial resistance Essential oil; pathogenic bacteria; biofilm; quorum sensing; microbial resistance
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MDPI and ACS Style

Cáceres, M.; Hidalgo, W.; Stashenko, E.; Torres, R.; Ortiz, C. Essential Oils of Aromatic Plants with Antibacterial, Anti-Biofilm and Anti-Quorum Sensing Activities against Pathogenic Bacteria. Antibiotics 2020, 9, 147. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040147

AMA Style

Cáceres M, Hidalgo W, Stashenko E, Torres R, Ortiz C. Essential Oils of Aromatic Plants with Antibacterial, Anti-Biofilm and Anti-Quorum Sensing Activities against Pathogenic Bacteria. Antibiotics. 2020; 9(4):147. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040147

Chicago/Turabian Style

Cáceres, Marlon, William Hidalgo, Elena Stashenko, Rodrigo Torres, and Claudia Ortiz. 2020. "Essential Oils of Aromatic Plants with Antibacterial, Anti-Biofilm and Anti-Quorum Sensing Activities against Pathogenic Bacteria" Antibiotics 9, no. 4: 147. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040147

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