Next Article in Journal
Benzamide Derivatives Targeting the Cell Division Protein FtsZ: Modifications of the Linker and the Benzodioxane Scaffold and Their Effects on Antimicrobial Activity
Previous Article in Journal
What Resources Do NHS Commissioning Organisations Use to Support Antimicrobial Stewardship in Primary Care in England?
Previous Article in Special Issue
Rosmarinus officinalis L. (Rosemary) Extracts Containing Carnosic Acid and Carnosol are Potent Quorum Sensing Inhibitors of Staphylococcus aureus Virulence
Editorial

Innate Antimicrobial Defense of Skin and Oral Mucosa

1
University of Iowa, Iowa City, IA 52240, USA
2
R&D Manager Hygiene Personal Care, Reckitt Benckiser, Parsippany, NJ 07054, USA
*
Author to whom correspondence should be addressed.
Received: 5 December 2019 / Accepted: 17 December 2019 / Published: 3 April 2020
(This article belongs to the Special Issue Innate Antimicrobial Defense of Skin and Oral Mucosa)
This special issue intends to review and update our understanding of the antimicrobial defense mechanisms of the skin and oral cavity. These two environments are quite different in terms of water, pH, and nutrient availability, but have some common antimicrobial factors. The skin surface supports the growth of a limited range of microorganisms but provides a hostile environment for others. The growth of most microorganisms is prevented or limited by the low pH, scarcity of some nutrients such as phosphorus and the presence of antimicrobial peptides, including defensins and cathelicidins, and antimicrobial lipids, including certain fatty acids and long-chain bases. On the other hand, the oral cavity is a warm, moist, nutrient rich environment which supports the growth of diverse microflora. Saliva coating the oral soft and hard surfaces determines which microorganisms can adhere to these surfaces. Some salivary proteins bind to bacteria and prevent their attachment to surfaces. Other salivary peptides, including defensins, cathelicidins, and histatins are antimicrobial. Antimicrobial salivary proteins include lysozyme, lactoferrin, and lactoperoxidase. There are also antimicrobial fatty acids derived from salivary triglycerides and long-chain bases derived from oral epithelial sphingolipids. The various antimicrobial factors determine the microbiomes of the skin surface and the oral cavity. Alterations of these factors can result in colonization by opportunistic pathogens, and this may lead to infection. Neutrophils and lymphocytes in the connective tissue of skin and mucosa also contribute to innate immunity. View Full-Text
Keywords: antimicrobial lipid; antimicrobial peptides; lysozyme; nutrients; permeability barrier; pH antimicrobial lipid; antimicrobial peptides; lysozyme; nutrients; permeability barrier; pH
MDPI and ACS Style

Wertz, P.W.; de Szalay, S. Innate Antimicrobial Defense of Skin and Oral Mucosa. Antibiotics 2020, 9, 159. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040159

AMA Style

Wertz PW, de Szalay S. Innate Antimicrobial Defense of Skin and Oral Mucosa. Antibiotics. 2020; 9(4):159. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040159

Chicago/Turabian Style

Wertz, Philip W., and Sarah de Szalay. 2020. "Innate Antimicrobial Defense of Skin and Oral Mucosa" Antibiotics 9, no. 4: 159. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040159

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop