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Brief Report

Tolerance and Persister Formation in Oral Streptococci

Department of Oral Health & Medicine, University Center for Dental Medicine, University of Basel, 4058 Basel, Switzerland
Department Research, University Center for Dental Medicine, University of Basel, 4058 Basel, Switzerland
Author to whom correspondence should be addressed.
Received: 21 March 2020 / Revised: 2 April 2020 / Accepted: 6 April 2020 / Published: 8 April 2020
(This article belongs to the Special Issue Antibiotics and Antimicrobials in Dentistry)
The aim of this study was to analyze the potential influence of long-term exposure in subinhibitory concentrations of chlorhexidine on the emergence of tolerant and/or persistent cells in oral streptococci. The two oral streptococcal isolates S. mutans ATCC25175 and S. sobrinus ATCC33402 were incubated, after long-term subinhibitory exposure to chlorhexidine, in liquid growth media containing high concentrations of chlorhexidine. A distinct subpopulation of more chlorhexidine-tolerant cells could be detected in streptococci that had been previously exposed to subinhibitory concentrations of chlorhexidine but not in the control strains. These more biocide-tolerant and persisting microbial subpopulations might also arise in vivo. Therefore, the rational and proper use of antimicrobials in dentistry, especially when used over a long period of time, is crucial. View Full-Text
Keywords: streptococci; chlorhexidine; tolerance; persister streptococci; chlorhexidine; tolerance; persister
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MDPI and ACS Style

Suppiger, S.; Astasov-Frauenhoffer, M.; Schweizer, I.; Waltimo, T.; Kulik, E.M. Tolerance and Persister Formation in Oral Streptococci. Antibiotics 2020, 9, 167.

AMA Style

Suppiger S, Astasov-Frauenhoffer M, Schweizer I, Waltimo T, Kulik EM. Tolerance and Persister Formation in Oral Streptococci. Antibiotics. 2020; 9(4):167.

Chicago/Turabian Style

Suppiger, Stephanie, Monika Astasov-Frauenhoffer, Irene Schweizer, Tuomas Waltimo, and Eva M. Kulik 2020. "Tolerance and Persister Formation in Oral Streptococci" Antibiotics 9, no. 4: 167.

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