Next Article in Journal
Impact of Antimicrobial Stewardship Interventions on Appropriateness of Surgical Antibiotic Prophylaxis: How to Improve
Next Article in Special Issue
The Effectiveness of Chlorhexidine and Air Polishing System in the Treatment of Candida albicans Infected Dental Implants: An Experimental In Vitro Study
Previous Article in Journal / Special Issue
Taurolidine Acts on Bacterial Virulence Factors and Does Not Induce Resistance in Periodontitis-Associated Bacteria—An In-Vitro Study
Brief Report

Tolerance and Persister Formation in Oral Streptococci

1
Department of Oral Health & Medicine, University Center for Dental Medicine, University of Basel, 4058 Basel, Switzerland
2
Department Research, University Center for Dental Medicine, University of Basel, 4058 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Received: 21 March 2020 / Revised: 2 April 2020 / Accepted: 6 April 2020 / Published: 8 April 2020
(This article belongs to the Special Issue Antibiotics and Antimicrobials in Dentistry)
The aim of this study was to analyze the potential influence of long-term exposure in subinhibitory concentrations of chlorhexidine on the emergence of tolerant and/or persistent cells in oral streptococci. The two oral streptococcal isolates S. mutans ATCC25175 and S. sobrinus ATCC33402 were incubated, after long-term subinhibitory exposure to chlorhexidine, in liquid growth media containing high concentrations of chlorhexidine. A distinct subpopulation of more chlorhexidine-tolerant cells could be detected in streptococci that had been previously exposed to subinhibitory concentrations of chlorhexidine but not in the control strains. These more biocide-tolerant and persisting microbial subpopulations might also arise in vivo. Therefore, the rational and proper use of antimicrobials in dentistry, especially when used over a long period of time, is crucial. View Full-Text
Keywords: streptococci; chlorhexidine; tolerance; persister streptococci; chlorhexidine; tolerance; persister
Show Figures

Figure 1

MDPI and ACS Style

Suppiger, S.; Astasov-Frauenhoffer, M.; Schweizer, I.; Waltimo, T.; Kulik, E.M. Tolerance and Persister Formation in Oral Streptococci. Antibiotics 2020, 9, 167. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040167

AMA Style

Suppiger S, Astasov-Frauenhoffer M, Schweizer I, Waltimo T, Kulik EM. Tolerance and Persister Formation in Oral Streptococci. Antibiotics. 2020; 9(4):167. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040167

Chicago/Turabian Style

Suppiger, Stephanie, Monika Astasov-Frauenhoffer, Irene Schweizer, Tuomas Waltimo, and Eva M. Kulik 2020. "Tolerance and Persister Formation in Oral Streptococci" Antibiotics 9, no. 4: 167. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040167

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop