Next Article in Journal
Polyphasic Validation of a Nisin-Biogel to Control Canine Periodontal Disease
Previous Article in Journal
Pan-Drug Resistant Acinetobacter baumannii, but Not Other Strains, Are Resistant to the Bee Venom Peptide Melittin
Previous Article in Special Issue
Tolerance and Persister Formation in Oral Streptococci
Article

The Effectiveness of Chlorhexidine and Air Polishing System in the Treatment of Candida albicans Infected Dental Implants: An Experimental In Vitro Study

1
Department of Head and Neck, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Gemelli, 00168 Rome, Italy
2
Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
3
Department of Oral Surgery and Implantology, University of Rome La Sapienza, 00161 Rome, Italy
4
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Received: 21 March 2020 / Revised: 6 April 2020 / Accepted: 8 April 2020 / Published: 14 April 2020
(This article belongs to the Special Issue Antibiotics and Antimicrobials in Dentistry)
Background: Peri-implantitis is an inflammatory disease with an increasing diffusion rate which can affect the long-term survival of a prosthetic rehabilitation. The present study focused on the decontaminating efficacy of chlorhexidine and air polishing system with sodium bicarbonate powder against Candida albicans, a microorganism which seems to have a superinfecting opportunistic role in the pathology. The aim of the authors was to investigate and compare the effectiveness of these treatments, commonly used in clinical practice. Methods: An in vitro study was conducted to analyze the effects of two widely used therapeutic aids for the disinfection of affected titanium implants: chlorhexidine (CHX) and air polishing with sodium bicarbonate powder (P). A qualitative and quantitative comparative analysis of the residual biofilm was carried out using a colorimetric assay (XTT) and scanning electron microscopy (SEM) observation. The experiment was conducted both on machined titanium surfaces and on rough sandblasted ones with the aim of bringing out differences in the therapeutic outcomes concerning the superficial texture of the implant. The null hypothesis was that no difference could be detected between the samples, regarding both the treatments performed and the nano-structural features of titanium. Results: The best results (on both types of implant surfaces) were obtained when combining the use of chlorhexidine and air polishing (C + P). A linear decrease in the optical density (OD) values recorded at three different time points (30 s, 1 min, 5 min) was also observed passing from the first to the last one. When observed under scanning electron microscope rough surfaces showed an extensive and highly structured biofilm, more complex if compared to the one encountered when analyzing machined implants. Conclusions: the present pilot study showed that rough surfaces can promote fungal adhesion and eventually hinder the outcome of a decontaminating treatment. For this purpose, the physio-chemical technique is always more efficient if compared to a single-technique approach regardless of the surface characteristics. View Full-Text
Keywords: Candida albicans; chlorhexidine; dental implants; peri-implantitis Candida albicans; chlorhexidine; dental implants; peri-implantitis
Show Figures

Figure 1

MDPI and ACS Style

Passarelli, P.C.; De Leonardis, M.; Piccirillo, G.B.; Desantis, V.; Papa, R.; Rella, E.; Mastandrea Bonaviri, G.N.; Papi, P.; Pompa, G.; Pasquantonio, G.; Manicone, P.F.; D’Addona, A. The Effectiveness of Chlorhexidine and Air Polishing System in the Treatment of Candida albicans Infected Dental Implants: An Experimental In Vitro Study. Antibiotics 2020, 9, 179. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040179

AMA Style

Passarelli PC, De Leonardis M, Piccirillo GB, Desantis V, Papa R, Rella E, Mastandrea Bonaviri GN, Papi P, Pompa G, Pasquantonio G, Manicone PF, D’Addona A. The Effectiveness of Chlorhexidine and Air Polishing System in the Treatment of Candida albicans Infected Dental Implants: An Experimental In Vitro Study. Antibiotics. 2020; 9(4):179. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040179

Chicago/Turabian Style

Passarelli, Pier C., Marta De Leonardis, Giovan B. Piccirillo, Viviana Desantis, Raffaele Papa, Edoardo Rella, Giuseppe N. Mastandrea Bonaviri, Piero Papi, Giorgio Pompa, Guido Pasquantonio, Paolo F. Manicone, and Antonio D’Addona. 2020. "The Effectiveness of Chlorhexidine and Air Polishing System in the Treatment of Candida albicans Infected Dental Implants: An Experimental In Vitro Study" Antibiotics 9, no. 4: 179. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040179

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop