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Open AccessReview

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

1
Department of Pharmaceutical Sciences, School of Pharmacy, Lebanese International University, Bekaa Campuses, Beirut, Lebanon
2
College of Natural and Health Sciences, Zayed University, Dubai, UAE
*
Author to whom correspondence should be addressed.
Joint first authors with equal contribution.
Received: 24 February 2020 / Revised: 29 March 2020 / Accepted: 1 April 2020 / Published: 16 April 2020
Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent the most potent β-lactamases, which hydrolyze a broad variety of β-lactams, including carbapenems, cephalosporins, penicillin, and aztreonam. The major issues associated with carbapenemase production are clinical due to compromising the activity of the last resort antibiotics used for treating serious infections, and epidemiological due to their dissemination into various bacteria across almost all geographic regions. Carbapenemase-producing Enterobacteriaceae have received more attention upon their first report in the early 1990s. Currently, there is increased awareness of the impact of nonfermenting bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa, as well as other Gram-negative bacteria that are carbapenemase-producers. Outside the scope of clinical importance, carbapenemases are also detected in bacteria from environmental and zoonotic niches, which raises greater concerns over their prevalence, and the need for public health measures to control consequences of their propagation. The aims of the current review are to define and categorize the different families of carbapenemases, and to overview the main lines of their spread across different bacterial groups. View Full-Text
Keywords: carbapenemases; β-lactamases; Gram-negative bacteria; resistance; KPC; metallo-β-lactamases; oxacillinases carbapenemases; β-lactamases; Gram-negative bacteria; resistance; KPC; metallo-β-lactamases; oxacillinases
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MDPI and ACS Style

Hammoudi Halat, D.; Ayoub Moubareck, C. The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria. Antibiotics 2020, 9, 186. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040186

AMA Style

Hammoudi Halat D, Ayoub Moubareck C. The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria. Antibiotics. 2020; 9(4):186. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040186

Chicago/Turabian Style

Hammoudi Halat, Dalal; Ayoub Moubareck, Carole. 2020. "The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria" Antibiotics 9, no. 4: 186. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040186

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