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Open AccessArticle

Assessment of the Usefulness of Cefapirin and Cefalonium Disks for Susceptibility Testing of Staphylococcus aureus Isolates from Bovine Mastitis

1
Department of Veterinary Internal Medicine, Tottori University, Tottori 680-8553, Japan
2
Laboratory of Veterinary Microbiology, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan
3
Ohnishi Laboratory of Veterinary Microbiology, Hokkaido 086-1106, Japan
*
Author to whom correspondence should be addressed.
Received: 25 March 2020 / Revised: 19 April 2020 / Accepted: 20 April 2020 / Published: 21 April 2020
(This article belongs to the Special Issue Antimicrobial Resistance in Pathogens Isolated from Animals)
Cefapirin (CEP) and cefalonium (CNM) are first-generation cephalosporins widely used to treat bovine mastitis caused by Gram-positive bacteria including staphylococci. However, disks for susceptibility testing of those drugs in causative bacteria are not available. This study evaluated the efficacy of 10 µg and 30 µg pilot disks of CEP (CEP10 and CEP30) and CNM (CNM10 and CNM30) against 130 Staphylococcus aureus isolates from bovine mastitis. Scattergrams of minimum inhibitory concentrations (MICs) and zone diameters (ZDs) illustrated significant correlations between the MICs and ZDs of CEP10 (r = −0.912), CEP30 (r = −0.933), CNM10 (r = −0.847), and CNM30 (r = −0.807). The analysis by Normalized Resistance Interpretation indicated that the epidemiolocal cut-off value (ECV) of MIC for both cefapirin and cefalonium is ≤ 0.5 µg/mL, and the ECV of ZD for CEP10, CEP30, CNM10, and CNM30 were ≥ 22 mm, ≥ 25 mm, ≥ 22 mm, and ≥ 29 mm, respectively. We believe that both 10 μg and 30 μg CEP and CNM susceptibility disks will be helpful for guiding the appropriate use of these antibiotics for bovine mastitis. Further studies toward the establishment of clinical breakpoint of CEP and CNM would be needed for their routine use. View Full-Text
Keywords: bovine mastitis; antimicrobial disk; staphylococci; cefapirin; cefalonium bovine mastitis; antimicrobial disk; staphylococci; cefapirin; cefalonium
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MDPI and ACS Style

Harada, K.; Irie, S.; Ohnishi, M.; Kataoka, Y. Assessment of the Usefulness of Cefapirin and Cefalonium Disks for Susceptibility Testing of Staphylococcus aureus Isolates from Bovine Mastitis. Antibiotics 2020, 9, 197. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040197

AMA Style

Harada K, Irie S, Ohnishi M, Kataoka Y. Assessment of the Usefulness of Cefapirin and Cefalonium Disks for Susceptibility Testing of Staphylococcus aureus Isolates from Bovine Mastitis. Antibiotics. 2020; 9(4):197. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040197

Chicago/Turabian Style

Harada, Kazuki; Irie, Shieri; Ohnishi, Mamoru; Kataoka, Yasushi. 2020. "Assessment of the Usefulness of Cefapirin and Cefalonium Disks for Susceptibility Testing of Staphylococcus aureus Isolates from Bovine Mastitis" Antibiotics 9, no. 4: 197. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9040197

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