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Acinetobacter baumannii Resistance: A Real Challenge for Clinicians

Departamento de Microbiología del Centro de Investigación en Ciencias de la Salud (CICSA), FCS, Universidad Anáhuac México Norte, Huixquilucan 52786, Mexico
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico
Medical IMPACT, Infectious Diseases Department, Mexico City 53900, Mexico
Coordinación Ciclos Clínicos Medicina, FCS, Universidad Anáhuac México Norte, Huixquilucan 52786, Mexico
Laboratorio de Medicina Genómica, Hospital Regional “1º de Octubre”, ISSSTE, Av. Instituto Politécnico Nacional 1669, Lindavista, Gustavo A. Madero, Ciudad de Mexico 07300, Mexico
Dirección Sistema Universitario de Salud de la Universidad Anáhuac México (SUSA), Huixquilucan 52786, Mexico
Author to whom correspondence should be addressed.
Received: 14 December 2019 / Revised: 29 January 2020 / Accepted: 5 February 2020 / Published: 23 April 2020
Acinetobacter baumannii (named in honor of the American bacteriologists Paul and Linda Baumann) is a Gram-negative, multidrug-resistant (MDR) pathogen that causes nosocomial infections, especially in intensive care units (ICUs) and immunocompromised patients with central venous catheters. A. baumannii has developed a broad spectrum of antimicrobial resistance, associated with a higher mortality rate among infected patients compared with other non-baumannii species. In terms of clinical impact, resistant strains are associated with increases in both in-hospital length of stay and mortality. A. baumannii can cause a variety of infections; most involve the respiratory tract, especially ventilator-associated pneumonia, but bacteremia and skin wound infections have also been reported, the latter of which has been prominently observed in the context of war-related trauma. Cases of meningitis associated with A. baumannii have been documented. The most common risk factor for the acquisition of MDR A baumannii is previous antibiotic use, following by mechanical ventilation, length of ICU/hospital stay, severity of illness, and use of medical devices. Current efforts focus on addressing all the antimicrobial resistance mechanisms described in A. baumannii, with the objective of identifying the most promising therapeutic scheme. Bacteriophage- and artilysin-based therapeutic approaches have been described as effective, but further research into their clinical use is required View Full-Text
Keywords: Acinetobacter baumannii; antibiotic resistance; septicemia Acinetobacter baumannii; antibiotic resistance; septicemia
MDPI and ACS Style

Vázquez-López, R.; Solano-Gálvez, S.G.; Juárez Vignon-Whaley, J.J.; Abello Vaamonde, J.A.; Padró Alonzo, L.A.; Rivera Reséndiz, A.; Muleiro Álvarez, M.; Vega López, E.N.; Franyuti-Kelly, G.; Álvarez-Hernández, D.A.; Moncaleano Guzmán, V.; Juárez Bañuelos, J.E.; Marcos Felix, J.; González Barrios, J.A.; Barrientos Fortes, T. Acinetobacter baumannii Resistance: A Real Challenge for Clinicians. Antibiotics 2020, 9, 205.

AMA Style

Vázquez-López R, Solano-Gálvez SG, Juárez Vignon-Whaley JJ, Abello Vaamonde JA, Padró Alonzo LA, Rivera Reséndiz A, Muleiro Álvarez M, Vega López EN, Franyuti-Kelly G, Álvarez-Hernández DA, Moncaleano Guzmán V, Juárez Bañuelos JE, Marcos Felix J, González Barrios JA, Barrientos Fortes T. Acinetobacter baumannii Resistance: A Real Challenge for Clinicians. Antibiotics. 2020; 9(4):205.

Chicago/Turabian Style

Vázquez-López, Rosalino, Sandra G. Solano-Gálvez, Juan J. Juárez Vignon-Whaley, Jorge A. Abello Vaamonde, Luis A. Padró Alonzo, Andrés Rivera Reséndiz, Mauricio Muleiro Álvarez, Eunice N. Vega López, Giorgio Franyuti-Kelly, Diego A. Álvarez-Hernández, Valentina Moncaleano Guzmán, Jorge E. Juárez Bañuelos, José Marcos Felix, Juan A. González Barrios, and Tomás Barrientos Fortes. 2020. "Acinetobacter baumannii Resistance: A Real Challenge for Clinicians" Antibiotics 9, no. 4: 205.

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