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Review

The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections

1
Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
2
Department of Chemistry and Technology of Drugs, “Department of Excellence 2018−2022”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
3
Center For Life Nano [email protected], Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy
*
Authors to whom correspondence should be addressed.
These authors equally contributed to the work.
Received: 18 May 2020 / Revised: 3 June 2020 / Accepted: 10 June 2020 / Published: 13 June 2020
The discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance of resistant strains. On the other hand, research in the field of drug-discovery has revaluated the potential of natural products as a unique source for new biologically active molecules and scaffolds for the medicinal chemistry. In this review, we first contextualized the worldwide problem of antibiotic resistance and the importance that natural products of plant origin acquire as a source of new lead compounds. We then focused on terpenes and their potential development as antimicrobials, highlighting those studies that showed an activity against conventional antibiotic-resistant strains. View Full-Text
Keywords: antibiotic resistance; plant secondary metabolites; plant-derived natural products; terpenes; diterpenes; triterpenes; multidrug-resistant strains. antibiotic resistance; plant secondary metabolites; plant-derived natural products; terpenes; diterpenes; triterpenes; multidrug-resistant strains.
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MDPI and ACS Style

Cappiello, F.; Loffredo, M.R.; Del Plato, C.; Cammarone, S.; Casciaro, B.; Quaglio, D.; Mangoni, M.L.; Botta, B.; Ghirga, F. The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections. Antibiotics 2020, 9, 325. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9060325

AMA Style

Cappiello F, Loffredo MR, Del Plato C, Cammarone S, Casciaro B, Quaglio D, Mangoni ML, Botta B, Ghirga F. The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections. Antibiotics. 2020; 9(6):325. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9060325

Chicago/Turabian Style

Cappiello, Floriana, Maria R. Loffredo, Cristina Del Plato, Silvia Cammarone, Bruno Casciaro, Deborah Quaglio, Maria L. Mangoni, Bruno Botta, and Francesca Ghirga. 2020. "The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections" Antibiotics 9, no. 6: 325. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9060325

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