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Open AccessArticle

Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk

1
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
2
Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy
3
Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue 49000, Vietnam
4
Mientrung Institute for Scientific Research, VAST, Hue 49000, Vietnam
5
Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50900 Tartu, Estonia
6
Institute of Biomolecular Chemistry (CNR), Li Punti, 07100 Sassari, Italy
7
Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy
*
Authors to whom correspondence should be addressed.
Both authors equally contributed to this paper.
Received: 28 May 2020 / Revised: 12 June 2020 / Accepted: 16 June 2020 / Published: 18 June 2020
The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antiviral activities of essential oils from the leaves, rhizomes, and whole plant of Hornstedtia bella were investigated. The GC/MS analysis showed that β-pinene, E-β-caryophyllene, and α-humulene were found at high concentrations in the essential oils. The essential oils exhibited (i) inhibition against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis with minimum inhibitory concentrations (MIC) and minimum lethal concentration (MLC) values from 1 to 4% (v/v); (ii) MIC and MLC values from 2 to 16% (v/v) in Candida tropicalis and Candida parapsilosis; (iii) MIC and MLC values from 4 to 16% in Enterococcus faecalis; and (iv) MIC and MLC values from 8 to greater than or equal to 16% (v/v) in the remaining strains, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, and Candida glabrata. In antitrichomonas activity, the leaves and whole-plant oils of Hornstedtia bella possessed IC50, IC90, and MLC values of 0.008%, 0.016%, and 0.03% (v/v), respectively, whilst those of rhizomes oil had in turn, 0.004%, 0.008%, and 0.016% (v/v).Besides, the leaf oil showed a weak cytotoxicity against Vero 76 and MRC-5; meanwhile, rhizomes and whole-plant oils did not exert any toxic effects on cell monolayers. Finally, these oils were not active against EV-A71. View Full-Text
Keywords: essential oils; infections; antifungal activity; antimicrobial activity essential oils; infections; antifungal activity; antimicrobial activity
MDPI and ACS Style

Donadu, M.G.; Trong Le, N.; Viet Ho, D.; Quoc Doan, T.; Tuan Le, A.; Raal, A.; Usai, M.; Marchetti, M.; Sanna, G.; Madeddu, S.; Rappelli, P.; Diaz, N.; Molicotti, P.; Carta, A.; Piras, S.; Usai, D.; Thi Nguyen, H.; Cappuccinelli, P.; Zanetti, S. Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk. Antibiotics 2020, 9, 334. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9060334

AMA Style

Donadu MG, Trong Le N, Viet Ho D, Quoc Doan T, Tuan Le A, Raal A, Usai M, Marchetti M, Sanna G, Madeddu S, Rappelli P, Diaz N, Molicotti P, Carta A, Piras S, Usai D, Thi Nguyen H, Cappuccinelli P, Zanetti S. Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk. Antibiotics. 2020; 9(6):334. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9060334

Chicago/Turabian Style

Donadu, Matthew G.; Trong Le, Nhan; Viet Ho, Duc; Quoc Doan, Tuan; Tuan Le, Anh; Raal, Ain; Usai, Marianna; Marchetti, Mauro; Sanna, Giuseppina; Madeddu, Silvia; Rappelli, Paola; Diaz, Nicia; Molicotti, Paola; Carta, Antonio; Piras, Sandra; Usai, Donatella; Thi Nguyen, Hoai; Cappuccinelli, Piero; Zanetti, Stefania. 2020. "Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk" Antibiotics 9, no. 6: 334. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9060334

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