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Open AccessArticle

Antibiotic Resistance in Nosocomial Bacteria Isolated from Infected Wounds of Hospitalized Patients in Czech Republic

1
Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University, and University Hospital, 779 00 Olomouc, Czech Republic
2
Department of Microbiology, Thomayer Hospital, 140 59 Prague, Czech Republic
3
Institute of Clinical Microbiology, Charles University Medical School and University Hospital, 500 05 Hradec Kralove, Czech Republic
4
Faculty of Military Health Sciences, University of Defence, 500 01 Hradec Kralove, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 6 May 2020 / Revised: 5 June 2020 / Accepted: 17 June 2020 / Published: 18 June 2020
(This article belongs to the Special Issue Antimicrobial Alternatives against Antimicrobial-Resistant Pathogens)
Hospitalized patients with wounds face an increased risk of infection with multi-drug-resistant nosocomial bacteria. In this study, samples from almost 10,000 patients from big hospitals in Czech Republic with infected wounds were analyzed for the presence of bacterial pathogens. In 7693 patients (78.8%), bacterial etiological agents were identified. Members of the Enterobacterales (37.1%) and Staphyloccus aureus (21.1%) were the most prevalent pathogens. Staphyloccus aureus showed methicillin resistance in 8.6%. Almost half of the Klebsiella pneumoniae isolates were ESBL-positive and 25.6% of the Enterobacter spp. isolates were AmpC-positive. The third most prevalent Pseudomonas aeruginosa showed resistance to 19–32% of the antipseudomonal antibiotics tested. Based on the results, amoxicillin/clavulanic acid, ampicillin/sulbactam or piperacillin/tazobactam combined with gentamicin can be recommended for antibiotic treatment of infected wounds. Once the etiological agent is identified, the therapy should be adjusted according to the species and its resistance. View Full-Text
Keywords: nosocomial; wound infection; resistance nosocomial; wound infection; resistance
MDPI and ACS Style

Kolar, M.; Cermak, P.; Hobzova, L.; Bogdanova, K.; Neradova, K.; Mlynarcik, P.; Bostik, P. Antibiotic Resistance in Nosocomial Bacteria Isolated from Infected Wounds of Hospitalized Patients in Czech Republic. Antibiotics 2020, 9, 342. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9060342

AMA Style

Kolar M, Cermak P, Hobzova L, Bogdanova K, Neradova K, Mlynarcik P, Bostik P. Antibiotic Resistance in Nosocomial Bacteria Isolated from Infected Wounds of Hospitalized Patients in Czech Republic. Antibiotics. 2020; 9(6):342. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9060342

Chicago/Turabian Style

Kolar, Milan; Cermak, Pavel; Hobzova, Lenka; Bogdanova, Katerina; Neradova, Katerina; Mlynarcik, Patrik; Bostik, Pavel. 2020. "Antibiotic Resistance in Nosocomial Bacteria Isolated from Infected Wounds of Hospitalized Patients in Czech Republic" Antibiotics 9, no. 6: 342. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9060342

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