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Open AccessArticle

Current Antibiotic Resistance Trends of Uropathogens in Central Europe: Survey from a Tertiary Hospital Urology Department 2011–2019

1
Department of Urology, 3rd Faculty of Medicine, Charles University and Thomayer Hospital, Videnska 800, 140 59 Prague, Czech Republic
2
Department of Clinical Microbiology, Thomayer Hospital, Videnska 800, 140 59 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 10 August 2020 / Revised: 17 September 2020 / Accepted: 20 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Antibiotics Use and Antimicrobial Resistance in Hospital)
Monitoring of pathogen resistance profiles is necessary to guide empirical antibiotic therapy before culture and sensitivity results become available. The aim of this study was to describe current antibiotic resistance patterns of five most frequent causative uropathogens in a Department of Urology of a tertiary referral centre in Central Europe over a period of nine years. The Hospital Department of Clinical Microbiology database was used to extract data on all positive urine samples from inpatients in the Department of Urology between 2011 and 2019. Numbers of susceptible and resistant isolates per year were calculated for five most frequent uropathogens: Escherichia coli, Enterococcus spp., Klebsiella spp., Pseudomonas aeruginosa, and Proteus spp. Antimicrobial agents selected for the survey included: ampicillin, amoxicillin/clavulanic acid, piperacillin/tazobactam; cefuroxime, cefotaxime, ceftazidime and cefepime; ciprofloxacin and ofloxacin; gentamicin and amikacin; ertapenem, meropenem and imipenem; trimethoprim-sulfamethoxazole (co-trimoxazole), nitrofurantoin, colistin, and vancomycin. High resistance rates of Gram-negative uropathogens were demonstrated to most common antimicrobials, with statistically significant increasing or decreasing trends in some cases. No carbapenem-resistant Enterobacteriaceae were isolated. Vancomycin-resistant Enterococcus spp. strains were rare in our population. View Full-Text
Keywords: antibiotics; Enterobateriaceae; resistance; urinary tract infection; E. coli; Klebsiella; Proteus; Pseudomonas; Enterococcus antibiotics; Enterobateriaceae; resistance; urinary tract infection; E. coli; Klebsiella; Proteus; Pseudomonas; Enterococcus
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MDPI and ACS Style

Hrbacek, J.; Cermak, P.; Zachoval, R. Current Antibiotic Resistance Trends of Uropathogens in Central Europe: Survey from a Tertiary Hospital Urology Department 2011–2019. Antibiotics 2020, 9, 630. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090630

AMA Style

Hrbacek J, Cermak P, Zachoval R. Current Antibiotic Resistance Trends of Uropathogens in Central Europe: Survey from a Tertiary Hospital Urology Department 2011–2019. Antibiotics. 2020; 9(9):630. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090630

Chicago/Turabian Style

Hrbacek, Jan; Cermak, Pavel; Zachoval, Roman. 2020. "Current Antibiotic Resistance Trends of Uropathogens in Central Europe: Survey from a Tertiary Hospital Urology Department 2011–2019" Antibiotics 9, no. 9: 630. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090630

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