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Antibiotics
Volume 9
Issue 9
10.3390/antibiotics9090632
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Open AccessReview

Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance

by
Matteo Bassetti
1,2,
Antonio Vena
1,*,
Chiara Sepulcri
1,
Daniele Roberto Giacobbe
1 and
Maddalena Peghin
3
1
Clinica Malattie Infettive, Ospedale Policlinico San Martino—IRCCS, 16132 Genoa, Italy
2
Department of Health Sciences, University of Genoa, 16132 Genoa, Italy
3
Department of Medicine, Infectious Diseases Clinic, University of Udine and Azienda Sanitaria Universitaria Integrata, 33100 Udine, Italy
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(9), 632; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090632
Received: 7 July 2020 / Revised: 31 August 2020 / Accepted: 13 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Gram-Negative Bloodstream Infections)
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Abstract

The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms of antibiotic resistance, epidemiology and treatment options for BSI caused by GNB with DTR, namely extended-spectrum Beta-lactamase-producing Enterobacteriales; carbapenem-resistant Enterobacteriales; DTR Pseudomonas aeruginosa; and DTR Acinetobacter baumannii. View Full-Text
Keywords: Gram-negative bacteria; difficult to treat bacteria; Enterobacteriales; Pseudomonas aeruginosa; Acinetobacter baumannii Gram-negative bacteria; difficult to treat bacteria; Enterobacteriales; Pseudomonas aeruginosa; Acinetobacter baumannii
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Bassetti, M.; Vena, A.; Sepulcri, C.; Giacobbe, D.R.; Peghin, M. Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance. Antibiotics 2020, 9, 632. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090632

AMA Style

Bassetti M, Vena A, Sepulcri C, Giacobbe DR, Peghin M. Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance. Antibiotics. 2020; 9(9):632. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090632

Chicago/Turabian Style

Bassetti, Matteo; Vena, Antonio; Sepulcri, Chiara; Giacobbe, Daniele R.; Peghin, Maddalena. 2020. "Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance" Antibiotics 9, no. 9: 632. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090632

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