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Open AccessReview

Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance

1
Clinica Malattie Infettive, Ospedale Policlinico San Martino—IRCCS, 16132 Genoa, Italy
2
Department of Health Sciences, University of Genoa, 16132 Genoa, Italy
3
Department of Medicine, Infectious Diseases Clinic, University of Udine and Azienda Sanitaria Universitaria Integrata, 33100 Udine, Italy
*
Author to whom correspondence should be addressed.
Received: 7 July 2020 / Revised: 31 August 2020 / Accepted: 13 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Gram-Negative Bloodstream Infections)
The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms of antibiotic resistance, epidemiology and treatment options for BSI caused by GNB with DTR, namely extended-spectrum Beta-lactamase-producing Enterobacteriales; carbapenem-resistant Enterobacteriales; DTR Pseudomonas aeruginosa; and DTR Acinetobacter baumannii. View Full-Text
Keywords: Gram-negative bacteria; difficult to treat bacteria; Enterobacteriales; Pseudomonas aeruginosa; Acinetobacter baumannii Gram-negative bacteria; difficult to treat bacteria; Enterobacteriales; Pseudomonas aeruginosa; Acinetobacter baumannii
MDPI and ACS Style

Bassetti, M.; Vena, A.; Sepulcri, C.; Giacobbe, D.R.; Peghin, M. Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance. Antibiotics 2020, 9, 632. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090632

AMA Style

Bassetti M, Vena A, Sepulcri C, Giacobbe DR, Peghin M. Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance. Antibiotics. 2020; 9(9):632. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090632

Chicago/Turabian Style

Bassetti, Matteo; Vena, Antonio; Sepulcri, Chiara; Giacobbe, Daniele R.; Peghin, Maddalena. 2020. "Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance" Antibiotics 9, no. 9: 632. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9090632

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