In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology
NETRI, 69007 Lyon, France
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editors: Miranda A. Farage, Laurent Misery, Enzo Berardesca and Howard I. Maibach
Cosmetics 2022, 9(4), 67; https://0-doi-org.brum.beds.ac.uk/10.3390/cosmetics9040067
Received: 27 May 2022
/
Revised: 16 June 2022
/
Accepted: 17 June 2022
/
Published: 23 June 2022
(This article belongs to the Special Issue Sensitive Skin—The Disconnect between Subjective and Medical Diagnosis: Towards Bridging “Feelings” with “Seeing” It)
The skin is a protective organ, able to decode a wide range of tactile, thermal, or noxious stimuli. Some of the sensors belonging to the transient receptor potential (TRP) family, for example, TRPV1, can elicit capsaicin-induced heat pain or histamine-induced itching sensations. The sensory nerve fibers, whose soma is located in the trigeminal or the dorsal root ganglia, are able to carry signals from the skin’s sensory receptors toward the brain via the spinal cord. In some cases, in response to environmental factors, nerve endings might be hyper activated, leading to a sensitive skin syndrome (SSS). SSS affects about 50% of the population and is correlated with small-fiber neuropathies resulting in neuropathic pain. Thus, for cosmetical and pharmaceutical industries developing SSS treatments, the selection of relevant and predictive in vitro models is essential. In this article, we reviewed the different in vitro models developed for the assessment of skin and neuron interactions. In a second part, we presented the advantages of microfluidic devices and organ-on-chip models, with a focus on the first model we developed in this context.
View Full-Text
Keywords:
neuron; skin; sensitive skin; organ-on-chip; microfluidic device; TRPV
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Guichard, A.; Remoué, N.; Honegger, T. In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology. Cosmetics 2022, 9, 67. https://0-doi-org.brum.beds.ac.uk/10.3390/cosmetics9040067
AMA Style
Guichard A, Remoué N, Honegger T. In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology. Cosmetics. 2022; 9(4):67. https://0-doi-org.brum.beds.ac.uk/10.3390/cosmetics9040067
Chicago/Turabian StyleGuichard, Alexandre, Noëlle Remoué, and Thibault Honegger. 2022. "In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology" Cosmetics 9, no. 4: 67. https://0-doi-org.brum.beds.ac.uk/10.3390/cosmetics9040067
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
