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Brief Report

Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis

1
Department of Medicine, University of Riverside, Riverside, CA 92521, USA
2
Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok 10330, Thailand
3
Division of Cardiac Electrophysiology, University of Michigan Health Care, Ann Arbor, MI 48109, USA
4
Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
5
Department of Internal Medicine, University of Arizona, Tucson, AZ 85721, USA
6
Department of Cardiovascular Medicine, Emory University, Atlanta, GA 30322, USA
*
Authors to whom correspondence should be addressed.
Received: 31 August 2020 / Revised: 24 October 2020 / Accepted: 26 October 2020 / Published: 27 October 2020
Introduction: The incidence of acute myocardial injury (AMI) among Coronavirus Disease 19 (COVID-19)-infected patients remain unclear. We aimed to conduct a systematic review and meta-analysis to further explore the incidence AMI in these patients. Methods: We comprehensively searched the MEDLINE, EMBASE and Cochrane databases from their inception to August 2020. The included studies were prospective or retrospective cohort studies that reported the event rate of AMI in COVID-19 patients. Data from each study were combined using random-effects to calculate the pooled incidence with 95% confidence intervals. Results: We identified twenty-seven studies consisting of 8971 hospitalized COVID-19-infected patients. The study demonstrated that 20.0% (95% CI 16.1–23.8% with substantial heterogeneity (I2 = 94.9%)) of hospitalized COVID-19 patients had AMI. In addition, our meta-regression suggested that older age, male and comorbidities were associated with a higher risk of AMI. Conclusion: The incidence of COVID-19-related myocardial injury ranges from 16.1–23.8%. Further larger studies are anticipated, as the pandemic is still ongoing. View Full-Text
Keywords: coronavirus; COVID-19; myocardial injury; meta-analysis; systematic review coronavirus; COVID-19; myocardial injury; meta-analysis; systematic review
MDPI and ACS Style

Prasitlumkum, N.; Chokesuwattanaskul, R.; Thongprayoon, C.; Bathini, T.; Vallabhajosyula, S.; Cheungpasitporn, W. Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis. Diseases 2020, 8, 40. https://0-doi-org.brum.beds.ac.uk/10.3390/diseases8040040

AMA Style

Prasitlumkum N, Chokesuwattanaskul R, Thongprayoon C, Bathini T, Vallabhajosyula S, Cheungpasitporn W. Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis. Diseases. 2020; 8(4):40. https://0-doi-org.brum.beds.ac.uk/10.3390/diseases8040040

Chicago/Turabian Style

Prasitlumkum, Narut, Ronpichai Chokesuwattanaskul, Charat Thongprayoon, Tarun Bathini, Saraschandra Vallabhajosyula, and Wisit Cheungpasitporn. 2020. "Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis" Diseases 8, no. 4: 40. https://0-doi-org.brum.beds.ac.uk/10.3390/diseases8040040

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