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Article

Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients

1
Department of Pathology, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica
2
Department of Medicine, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica
*
Author to whom correspondence should be addressed.
Received: 1 December 2020 / Revised: 22 December 2020 / Accepted: 27 December 2020 / Published: 3 January 2021
(This article belongs to the Special Issue Chronic and Infectious Diseases)
Background: The progression of chronic kidney disease (CKD) is concomitant with complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. The aim of this study is to determine serum cystatin C levels, and the prevalence of vitamin D deficiency and thyroid dysfunction in CKD patients. Methods: A cross-sectional study was conducted involving 140 CKD patients (stages 1–5) that were referred to a renal clinic. Demographic data was collected and thyroid function tests, serum 25-OH-vitamin D, cystatin C levels, and routine biochemistry tests were determined using cobas 6000 analyzer. Results: 129 (92.1%) of CKD patients had elevated serum cystatin C levels and there was a stepwise increase from stage 1–5. Overt hypothyroidism was present in one patient and nine had subclinical hypothyroidism. There was a stepwise reduction in serum 25-OH-vitamin D levels from stage 2–5, 31 (22.1%) had vitamin D insufficiency and 31 (22.1%) presented with deficiency. Conclusions: 25-OH-vitamin D deficiency and thyroid disorders are exhibited in chronic kidney disease patients and the severity of the former rises with disease progression, as indicated by elevated cystatin C levels. Routine screening and timely intervention is recommended so as to reduce the risk of cardiovascular diseases. View Full-Text
Keywords: kidney; disease; thyroid; vitamin D; cystatin C; prevalence; deficiency; insufficiency; chronic kidney; disease; thyroid; vitamin D; cystatin C; prevalence; deficiency; insufficiency; chronic
MDPI and ACS Style

Tapper, M.; McGrowder, D.A.; Dilworth, L.; Soyibo, A. Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients. Diseases 2021, 9, 5. https://0-doi-org.brum.beds.ac.uk/10.3390/diseases9010005

AMA Style

Tapper M, McGrowder DA, Dilworth L, Soyibo A. Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients. Diseases. 2021; 9(1):5. https://0-doi-org.brum.beds.ac.uk/10.3390/diseases9010005

Chicago/Turabian Style

Tapper, Marlene, Donovan A. McGrowder, Lowell Dilworth, and Adedamola Soyibo. 2021. "Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients" Diseases 9, no. 1: 5. https://0-doi-org.brum.beds.ac.uk/10.3390/diseases9010005

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