Scientia Pharmaceutica

2304 KiB

Open AccessArticle

Preparation of MFP Microspheres Using Polyacrylate Resins for the Therapy of Osteoporosis

by A. Janka, B. Korsatko-Wabnegg and W. Korsatko

Sci. Pharm. 2000, 68(2), 213-221; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-00-20 - 01 Jun 2000

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Disodium Monofluorophoshate (MFP), a highly water soluble drug, was incorporated in polyacrylate resin microspheres by using the solvent-evaporation technique. The process is based on dispersing the acetone solution of the drug and the polymer in liquid paraffin. Eudragit RS 100/S 100 in a [...] Read more.

Disodium Monofluorophoshate (MFP), a highly water soluble drug, was incorporated in polyacrylate resin microspheres by using the solvent-evaporation technique. The process is based on dispersing the acetone solution of the drug and the polymer in liquid paraffin. Eudragit RS 100/S 100 in a 3:1 ratio turned out as the best coating material. The influence of the main manufacturing factors, namely polymer-drug ratio, addition of magnesium stearate, size of the beads, production temperature and speed of stirring, on the technological characteristics of the microspheres, like release rate of the drug, shape, drug-loading and size of the particle were investigated. The findings resulted in a formulation, which obtains the desired controlled release of the drug in a convenient oral system. Full article

2779 KiB

Open AccessArticle

Ion-pair Spectrophotometric Determination of Dibucaine

by Raqi M. Shubietah, Ali Z.Abu Zuhri and Bashar A. Khalid

Sci. Pharm. 2000, 68(2), 189-200; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-00-17 - 12 May 2000

Cited by 1 | Viewed by 771

Abstract

A simple and sensitive spectrophotometric determination of dibucain has been established. It is based on the formation of colored ion-pair complexes between Dibucaine and each of Orange II, Orange G, Bromothymol blue and Bromocresol green. The extract with each of the previous dyes [...] Read more.

A simple and sensitive spectrophotometric determination of dibucain has been established. It is based on the formation of colored ion-pair complexes between Dibucaine and each of Orange II, Orange G, Bromothymol blue and Bromocresol green. The extract with each of the previous dyes in chloroform exhibited a specific wavelength of maximum absorbance, and all these wavelengths lied in the range 416 to 500 nm. The linear range extended from 1.5 to 60 ppm. The optimum conditions were selected after studying many variables such as pH, shaking time, temperature and dye concentrations. The method was also selective for the analyte and the drug excipients did not interfere. Full article

4614 KiB

Open AccessArticle

A Simple Kinetic Spectrophotometric Method For The Determination of Certain 4-Quinolones in Drug Formulations.

by M. Rizk, F. Belal, F. Ibrahim, S. M. Ahmed and N. M. El-Enany

Sci. Pharm. 2000, 68(2), 173-188; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-00-16 - 10 May 2000

Cited by 26 | Viewed by 897

Abstract

An accurate simple and selective kinetic procedure for the determination of certain 4-quinolones namely, norfloxacin (I), ofloxacin (II), enrofloxacin (III), fleroxacin (IV), ciprofloxacin (V) and pefloxacin (VI) is described. The procedure is based on reacting the studied compounds in acidic media (0.1 M [...] Read more.

An accurate simple and selective kinetic procedure for the determination of certain 4-quinolones namely, norfloxacin (I), ofloxacin (II), enrofloxacin (III), fleroxacin (IV), ciprofloxacin (V) and pefloxacin (VI) is described. The procedure is based on reacting the studied compounds in acidic media (0.1 M HCL) with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in presence of cerium (IV) ammonium sulphate as an oxidant at room temperature for a fixed time of 20 min. for (I), (III), 12 min for (II) and 30 min for IV , V and VI, then the absorbance of the reaction product is measured at 630 nm. The concentration of the studied compounds is computed using the corresponding calibration curve equation for the fixed-time method. The absorbance-concentrations plot is rectilinear over the range 20-100 ug.ml^-1 for (I), 2 - 20 ug.ml^-1 for (II), 10 - 74 ug.ml^-1 for (III), 10 - 60 ug.ml^-1 for IV, 10 - 50 ug.ml^-1 for IV and 8 - 40 ug.ml^-1 for VI. The determination of the studied compounds by the fixed-concentration and rate constant methods is feasible with the calibration equation obtained, but the fixed-time method proved to be more applicable. The procedure was applied successfully to commercial tablets and ampoules and the results obtained were compared statistically with the reference methods. Full article

6556 KiB

Open AccessArticle

Androgenic and Anabolic Activities of Some Newly Synthesized Epiandrosterone and Progesterone Derivatives.

by Y. A. Maklad and M. M. Nosseir

Sci. Pharm. 2000, 68(2), 141-157; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-00-13 - 05 May 2000

Cited by 3 | Viewed by 1079

Abstract

Derivatives of eplandrosterone and progesterone were synthesized. The androgenic and the anabolic activities of some of tlieln were investigated on prepubertal male albino rats of 21 days old by:-i determining tlie weight gain of the body, levator ani muscle, ventral prostate gland, testis, [...] Read more.

Derivatives of eplandrosterone and progesterone were synthesized. The androgenic and the anabolic activities of some of tlieln were investigated on prepubertal male albino rats of 21 days old by:-i determining tlie weight gain of the body, levator ani muscle, ventral prostate gland, testis, selniilal vesicles, vas deferens and epididymis, ii- estimation of serum luteinizing (LH) hormone, iii- histopatliological examination of the testis and ventral prostate glands. The results from this study showed that the presence of an appended substituted 2- aminopyridine ring at the C- 17 of testosterone gave the maximum androgenic activity, whereas the presence of a substituted piperidine ring fused to ring D of 5 α- androstane exhibited tlie maximum anabolic activity. However, fusion of a pyrazoline moiety with the ring D of 5 α- androstane led to a compound with considerable androgenic and anabolic activity. Full article

2106 KiB

Open AccessArticle

Pharmacognostical examination concerning the hemostyptic effect of Achillea millefolium Aggregat

by U. Sellerberg and H. Glasl

Sci. Pharm. 2000, 68(2), 201-206; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-00-18 - 02 May 2000

Cited by 3 | Viewed by 1150

Abstract

Yarrow (Achillea mille/olium Aggregat) is traditionally used against bleeding. Aqueous hot extracts were turbid and shortened the recalcification time, a global test ofthe blood coagulation. The residue obtained by membrane filtration of these extracts was the active fraction. This residue is problably [...] Read more.

Yarrow (Achillea mille/olium Aggregat) is traditionally used against bleeding. Aqueous hot extracts were turbid and shortened the recalcification time, a global test ofthe blood coagulation. The residue obtained by membrane filtration of these extracts was the active fraction. This residue is problably located mostly in the stem. By pressure obtained juice elongated the blood coagulation. Compared with non-flowering and wilthed material, the blooming herb showed best effects. The storage conditions had no effect on the activity ofthe herb. Full article

1457 KiB

Open AccessArticle

Pyrrolizidine Alkaloids in Senecio nemorensis L. from Mongolia

by Helmut Wiedenfeld, Narantuya S., Altanchimeg D. and Erhard Roeder

Sci. Pharm. 2000, 68(2), 207-211; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-00-19 - 20 Apr 2000

Cited by 13 | Viewed by 922

Abstract

We isolated four Pyrrolizidine Alkaloids (PA) from Senecio nemorensis L. growing in Mongolia. Their structures were elucidated by spectroscopic methods to be 7-Senecioyl-9-sarracinoyl-retronecine, Retroisosenine, Doriasenine and Bulgarsenine. The alkaloidal pattern is very similar to that of the European Senecio nemorensis L., ssp. nemorensis [...] Read more.

We isolated four Pyrrolizidine Alkaloids (PA) from Senecio nemorensis L. growing in Mongolia. Their structures were elucidated by spectroscopic methods to be 7-Senecioyl-9-sarracinoyl-retronecine, Retroisosenine, Doriasenine and Bulgarsenine. The alkaloidal pattern is very similar to that of the European Senecio nemorensis L., ssp. nemorensis (Rchb.) Celak. The medicinal use of this plant or of preparations from it may be hazardous to human health because of the high PA level in the plant (≈ 0.1%) and the fact that three of the PA are known to have toxic side-effects. Full article

2844 KiB

Open AccessArticle

Dipeptidamide mit Süßstoffcharakter

by B. Unterhalt and L. Kerckhoff

Sci. Pharm. 2000, 68(2), 165-172; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-00-15 - 19 Apr 2000

Cited by 1 | Viewed by 736

Abstract

Several L-Aspartyl-D-alanin-2-methylcycloalkylamides (9a-h) were synthesized and tested for their sweet quality. Full article

1672 KiB

Open AccessArticle

Synthesis and Anticalcium Activity of New Compounds Containing the 2,3-Dihydro-1,4-dioxino[2,3-b]pyridine System

by I. Sánchez, MD. Pujol, G. Guillaumet, R. Massingham, A. Monteil, G. Dureng and E. Winslow

Sci. Pharm. 2000, 68(2), 159-164; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-00-14 - 05 Apr 2000

Cited by 9 | Viewed by 724

Abstract

Summary: New compounds (3 and 4) possesing the 2,3-dihydro-1,4-dioxino[2,3-b]pyridine group were synthesized and tested as calcium antagonist agents. Both of them showed moderate anticalcium activity. Full article

3133 KiB

Open AccessArticle

Die Reaktion des 2,3,4a,8a-Tetrachlor-6,7-dimethyl-4a,5,8,8a-tetrahydro-1,4-naphthochinons mit Aminen

by H.-J. Kallmayer and M. Doerr

Sci. Pharm. 2000, 68(2), 129-139; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-00-12 - 01 Apr 2000

Cited by 1 | Viewed by 780

Abstract

2,3,4a,8a-Tetrachloro-6,7-dimethyl-4a,5 ,8,8a-tetrahydro-1,4-naphthoquinone (5) reacts with arylamines 8a-e to give 2-amino-dihydroquinones 4a-e. Alkylamines 8f and h give 2-amino-dihydroquinones 4f, h and 2-amino-1,4-naphthoquinones 7f, h, dialkylamines 9f, g, i and j give 2-amino-dihydroqulnones [...] Read more.

2,3,4a,8a-Tetrachloro-6,7-dimethyl-4a,5 ,8,8a-tetrahydro-1,4-naphthoquinone (5) reacts with arylamines 8a-e to give 2-amino-dihydroquinones 4a-e. Alkylamines 8f and h give 2-amino-dihydroquinones 4f, h and 2-amino-1,4-naphthoquinones 7f, h, dialkylamines 9f, g, i and j give 2-amino-dihydroqulnones 3f, g, i, j, 2-amino-1,4-naphthoquinones 6f, g, i, j and the photodesalkylated products 10f and g. Full article

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Sci. Pharm., Volume 68, Issue 2 (June 2000) – 9 articles , Pages 129-221

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