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Sci. Pharm.
Volume 71
Issue 2
10.3797/scipharm.aut-03-06
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Article

Svnthesis of 3-(3.5-Dioxo-[1,2,4]-oxadiazolidin-2-vl)propylphosphonic Acids

by
Thomas Kurz
*,
Detlef Geffken
and
Claudia Wackendorff
Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2003, 71(2), 39-49; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-06
Submission received: 5 February 2003 / Revised: 4 April 2003 / Accepted: 4 April 2003 / Published: 5 April 2003
Versions Notes

Abstract

Cyclic carbonylation of hydroxyureas 3 with 1,1'-carbonyldiimidazole gave 3-(3,5-dioxo-[1,2,4]oxadiazolidin-2yl)propylphosphonic acid diethyl esters 4 which were converted into the corresponding phosphonic acids 5 with bromotrimethylsilane.
Keywords: Hydroxyureas; cyclic carbonylation; 1,2,4-oxadiazolidine-3,s-diones; phosphonic acids Hydroxyureas; cyclic carbonylation; 1,2,4-oxadiazolidine-3,s-diones; phosphonic acids

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MDPI and ACS Style

Kurz, T.; Geffken, D.; Wackendorff, C. Svnthesis of 3-(3.5-Dioxo-[1,2,4]-oxadiazolidin-2-vl)propylphosphonic Acids. Sci. Pharm. 2003, 71, 39-49. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-06

AMA Style

Kurz T, Geffken D, Wackendorff C. Svnthesis of 3-(3.5-Dioxo-[1,2,4]-oxadiazolidin-2-vl)propylphosphonic Acids. Scientia Pharmaceutica. 2003; 71(2):39-49. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-06

Chicago/Turabian Style

Kurz, Thomas, Detlef Geffken, and Claudia Wackendorff. 2003. "Svnthesis of 3-(3.5-Dioxo-[1,2,4]-oxadiazolidin-2-vl)propylphosphonic Acids" Scientia Pharmaceutica 71, no. 2: 39-49. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-06

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