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Sci. Pharm.
Volume 71
Issue 4
10.3797/scipharm.aut-03-27
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Effects Of 2-Methvl-3-propvnvlauinazolin-4-(3H)-one On Vascular Reactivitv In Isolated Porcine Tail Arteries

by
Odafenkhoa Ojeikere
1,
Cyril Usifoh
2 and
Anthony Ebeigbe
1,*
1
Departmenot f Physiology. University of Benin. Benin City, Nigeria
2
Departmenotf Pharmaceutical Chemistry. University of Benin. Benin City, Nigeria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2003, 71(4), 321-329; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-27
Submission received: 13 March 2003 / Revised: 4 June 2003 / Accepted: 4 June 2003 / Published: 10 November 2003
Versions Notes

Abstract

The vascular effects of 2-methyl-3-propynylquinazolin-4-(3H)-one (QUIN) have been studied on isolated porcine tail arteries. QUlN had no effect on resting tension but relaxed, dose-dependently, arteries precontracted with noradrenaline or high-K+ in the order: NA > high-K+. Also, QUlN inhibited both intracellular (ICD) and extracellular (ECD) Ca2+-dependent contractions in the order: ICD > ECD The results suggest that QUlN interferes with vascular Ca2+ mobilization.
Keywords: Quinazolinones; Vascular Reactivity; Smooth muscle Quinazolinones; Vascular Reactivity; Smooth muscle

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MDPI and ACS Style

Ojeikere, O.; Usifoh, C.; Ebeigbe, A. Effects Of 2-Methvl-3-propvnvlauinazolin-4-(3H)-one On Vascular Reactivitv In Isolated Porcine Tail Arteries. Sci. Pharm. 2003, 71, 321-329. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-27

AMA Style

Ojeikere O, Usifoh C, Ebeigbe A. Effects Of 2-Methvl-3-propvnvlauinazolin-4-(3H)-one On Vascular Reactivitv In Isolated Porcine Tail Arteries. Scientia Pharmaceutica. 2003; 71(4):321-329. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-27

Chicago/Turabian Style

Ojeikere, Odafenkhoa, Cyril Usifoh, and Anthony Ebeigbe. 2003. "Effects Of 2-Methvl-3-propvnvlauinazolin-4-(3H)-one On Vascular Reactivitv In Isolated Porcine Tail Arteries" Scientia Pharmaceutica 71, no. 4: 321-329. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-27

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