Next Issue
Volume 72, December
Previous Issue
Volume 72, June
 
 
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Sci. Pharm., Volume 72, Issue 3 (September 2004) – 6 articles

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Order results
Result details
Select all
Export citation of selected articles as:
2920 KiB  
Article
Analysis of the sesquiterpenes in Achillea species usinq liquid chromatography-mass spectrometry with positive ion atmospheric pressure chemical ionisation
by Katharina Rothwangl-Wiltschnigg, Sabine Glasl, Ingrid Werner and Gottfried Reznicek
Sci. Pharm. 2004, 72(3), 249-258; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-04-21 - 11 Sep 2004
Cited by 1 | Viewed by 1076
Abstract
The species of the Achillea millefolium group contain different sesquiterpenes which are of chemotaxonomical and pharmacological interest. Therefore the HPLC analysis of these compounds is a fundamental task for the quality control of Achillea samples. As difficulties in identification solely on the basis [...] Read more.
The species of the Achillea millefolium group contain different sesquiterpenes which are of chemotaxonomical and pharmacological interest. Therefore the HPLC analysis of these compounds is a fundamental task for the quality control of Achillea samples. As difficulties in identification solely on the basis of retention times may arise, the LC was coupled with atmospheric pressure chemical ionisation mass spectrometry (APCI-MS) allowing a selective and sensitive detection and thus the clear identification of the sesquiterpenes. Full article
3289 KiB  
Article
Differential Pulse Voltammetric Determination of Loperamide in a Pharmaceutical Dosaqe Form
by A. Radi and T. Elmogy
Sci. Pharm. 2004, 72(3), 239-248; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-04-20 - 09 Sep 2004
Cited by 3 | Viewed by 1074
Abstract
A voltammetric study of the oxidation of loperamide has been carried out at the glassy carbon electrode. This compound exhibited a single peak in Britton-Robinson buffer solutions of pH 5.0–11.0, with a maximum current at pH 8.0. The electrochemical oxidation of loperamide is [...] Read more.
A voltammetric study of the oxidation of loperamide has been carried out at the glassy carbon electrode. This compound exhibited a single peak in Britton-Robinson buffer solutions of pH 5.0–11.0, with a maximum current at pH 8.0. The electrochemical oxidation of loperamide is identified as an irreversible, diffusion-controlled process. Based on this study, a simple, rapid and sensitive voltammetric method was applied, without any interference from the excipients, to the determination of the drug in a capsule dosage form. Full article
3093 KiB  
Article
Comparative Bioavailabilitv Studv of Two Brands of Terbutaline Sulphate Tablets in Healthy Human Volunteers
by Nahla S. Barakat, Nawal M. Khalafallah and Said A. Khalil
Sci. Pharm. 2004, 72(3), 227-237; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-04-19 - 07 Sep 2004
Viewed by 1103
Abstract
The purpose of this study was to evaluate the bioavailability of locally produced 2.5 mg terbutaline sulphate tablets (brand A ) relative to a reference product, Bricanyl 2.5 mg tablets (brand 6). The study was a single dose 5 mg randomized crossover one [...] Read more.
The purpose of this study was to evaluate the bioavailability of locally produced 2.5 mg terbutaline sulphate tablets (brand A ) relative to a reference product, Bricanyl 2.5 mg tablets (brand 6). The study was a single dose 5 mg randomized crossover one in 15 healthy volunteers in the fasting state. Urine was collected at intervals of 24 h. Total terbutaline excreted in urine as unchanged drug and as conjugates (sulphate and glucuronide) was determined by a developed and validated HPLC method. In-vitro characteristics of both brands were similar. Based on percent of the dose excreted in urine, the oral bioavailability ranged from 33.5% to 75.8% for both brands. Statistics were applied to judge bioequivalence according to USP 24 in-vivo bioequivalence guidance. Results indicated that brand A and B were bioequivalent and hence interchangeable in medical practice. Full article
2506 KiB  
Article
A VALIDATED HPLC-ASSAY FOR THE DETERMINATION OF MELOXICAM IN PRESENCE OF ITS DEGRADATION PRODUCTS
by Herbert Bartsch, Angelika Eiper, Hannelore Kopelent-Frank and Jiři Procházka
Sci. Pharm. 2004, 72(3), 213-220; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-04-17 - 03 Sep 2004
Viewed by 1068
Abstract
The stability of aqueous solutions of meloxicam is studied with samples of different concentrations, and in different containers. Quantitation is carried out utilizing a validated stability indicating HPLC assay with five-point calibration. Sample solutions of meloxicam of three different concentrations (2 mg ml [...] Read more.
The stability of aqueous solutions of meloxicam is studied with samples of different concentrations, and in different containers. Quantitation is carried out utilizing a validated stability indicating HPLC assay with five-point calibration. Sample solutions of meloxicam of three different concentrations (2 mg ml−1; 250 µg ml−1; 40 µg ml−1) are subjected to simulated sunlight and tested for stability. A distinct correlation of the photodegradation rate with the concentration of the sample solution was found. Furthermore, the influence of size and geometry of the containers in which the solutions were exposed to light was investigated and results compared. Full article
4598 KiB  
Article
N-(3,4-Dichlorobenzyl)azoles—Investigations Regarding Synthesis, NMR-Spectroscopy and Affinity Towards Sisma-1 and Sigma-2 Receptors
by Wolfgang Holzer, Bettina Brandstätter, Christine Jäger, Michael Kaun, Thierry Langer and Wayne D. Bowen
Sci. Pharm. 2004, 72(3), 197-211; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-04-16 - 01 Sep 2004
Viewed by 1098
Abstract
A series of azoles and aminoazoles with a 3,4-dichlorobenzyl moiety attached to a ring nitrogen atom was synthesized via reaction of the parent systems with 3,4-dichlorobenzyl chloride. Regioisomeric products were discriminated on the basis of 13C-NMR data or by NOE-difference spectroscopy. The [...] Read more.
A series of azoles and aminoazoles with a 3,4-dichlorobenzyl moiety attached to a ring nitrogen atom was synthesized via reaction of the parent systems with 3,4-dichlorobenzyl chloride. Regioisomeric products were discriminated on the basis of 13C-NMR data or by NOE-difference spectroscopy. The affinities of some representatives towards sigma-1 and sigma-2 receptors were determined by receptor binding assays. Full article
1414 KiB  
Article
Study of local anesthetics. Part* 166:Conductometric determination of the critical micelle concentration of local anesthetic heptacainium chloride in aqueous electrolvte solution
by F. Andriamainty, J. Čižmárik and M. Holíková
Sci. Pharm. 2004, 72(3), 221-225; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-04-18 - 11 Aug 2004
Cited by 7 | Viewed by 898
Abstract
Specific conductivities of local anesthetic heptacainium chloride XlX (HCC XlX) (N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-piperidinium chloride), in aqueous electrolyte solution (0.05 mol.1−1 NaCl) were measured as a function of the concentration and temperature. The critical micelle concentrations (c.m.c) and the counterion (β) binding of the micelles [...] Read more.
Specific conductivities of local anesthetic heptacainium chloride XlX (HCC XlX) (N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-piperidinium chloride), in aqueous electrolyte solution (0.05 mol.1−1 NaCl) were measured as a function of the concentration and temperature. The critical micelle concentrations (c.m.c) and the counterion (β) binding of the micelles were estimated from the dependence of the specific conductivity of the substrate concentration. The temperature dependence of ln c.m.c was fitted to the function of the second degree polynomial. From the fitting parameters, Gibss free energies (ΔG0), enthalpies (ΔH0), and entropies (ΔS0) of micellization as a function of temperature were estimated. The "mass action model" was applied to micelle formation to calculate the micellization parameters. Full article
Previous Issue
Next Issue
Back to TopTop