Scientia Pharmaceutica

385 KiB

Open AccessArticle

Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7)

by Rana Abu-Dahab and Fatma Afifi

Sci. Pharm. 2007, 75(3), 121-146; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.2007.75.121 - 28 Sep 2007

Cited by 103 | Viewed by 3549

76 ethanolic extracts of medicinal herbs from the Jordanian flora, belonging to 67 species and 34 families, were evaluated for their antiproliferative activity on a breast cancer cell line (MCF7). The cells were cultured in RPMI 1640 medium and incubated with the extracts [...] Read more.

76 ethanolic extracts of medicinal herbs from the Jordanian flora, belonging to 67 species and 34 families, were evaluated for their antiproliferative activity on a breast cancer cell line (MCF7). The cells were cultured in RPMI 1640 medium and incubated with the extracts for 72 hours. Sulphorhodamine B (SRB) assay was used to test cytotoxicity.
From the tested crude extracts, Inula graveolens, Salvia dominica, Conyza canadiensis and Achillea santolina showed potent antiproliferative activity and the activity resided in the chloroform/ethanolic extracts. The most active plant was I. graveolens with an IC₅₀ of 3.83 μg/ml. Phytochemical screening indicated the presence of flavonoids, terpenoids, and phenolics in all active extracts. These results indicate the possible potential use of medicinal plants from the Jordanian flora as antineoplastic agents. Full article

305 KiB

Open AccessArticle

Two New Saponins from Solidago gigantea

by Angelika Lendl and Gottfried Reznicek

Sci. Pharm. 2007, 75(3), 111-120; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.2007.75.111 - 28 Sep 2007

Cited by 5 | Viewed by 1421

Abstract

Two new triterpenoid saponins, named giganteasaponin 5 and giganteasaponin 6, were isolated from the aboveground parts of Solidago gigantea and were defined to be 3-O-[β-D-Apio-D-furanosyl-(1→3)- β-D-glucopyranosyl-(1→3)- β-D-glucopyranosyl]- 28-O {α-L-rhamnopyranosyl-(1→3)- β-D-xylopyranosyl-(1→4)- [β-D-xylopyranosyl-( 1→3)]- α-L-rhamnopyranosyl-(1→2) [α-L-rhamnopyranosyl-(1→3)]- β-Dxylopyranosyl}- Bayogenin respectively 3-O- [β-D-Apio-D-furanosyl-(1→3)- β-Dgluco- pyranosyl-(1→3)- β-D-glucopyranosyl]-28-O {β-D-galactopyranosyl-(1→2)- [...] Read more.

Two new triterpenoid saponins, named giganteasaponin 5 and giganteasaponin 6, were isolated from the aboveground parts of Solidago gigantea and were defined to be 3-O-[β-D-Apio-D-furanosyl-(1→3)- β-D-glucopyranosyl-(1→3)- β-D-glucopyranosyl]- 28-O {α-L-rhamnopyranosyl-(1→3)- β-D-xylopyranosyl-(1→4)- [β-D-xylopyranosyl-( 1→3)]- α-L-rhamnopyranosyl-(1→2) [α-L-rhamnopyranosyl-(1→3)]- β-Dxylopyranosyl}- Bayogenin respectively 3-O- [β-D-Apio-D-furanosyl-(1→3)- β-Dgluco- pyranosyl-(1→3)- β-D-glucopyranosyl]-28-O {β-D-galactopyranosyl-(1→2)- α- L-rhamnopyranosyl-(1→3)- β-D-xylopyranosyl-(1→4)- [β-D-xylopyranosyl-(1→3)]- α-L-rhamnopyranosyl-(1→2) [α-L-rhamnopyranosyl-(1→3)]- β-D-xylopyranosyl}- Bayogenin. The structures were established on the basis of chemical degradation, extensive MS studies and NMR investigations as well. Full article

380 KiB

Open AccessArticle

In Vitro Release Studies on Multiple and Simple Emulsions of α-Tocopherol with Pistacia Leaves

by Ö. Özer, B. Kıvçak, B. Mutlu, S. Akay, H. Sağlam and S. Tömek

Sci. Pharm. 2007, 75(3), 97-110; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.2007.75.97 - 28 Sep 2007

Cited by 5 | Viewed by 1050

Abstract

α-Tocopherol is the most effective lipid soluble natural antioxidant and free-radical scavenger. The present study aimed to evaluate the performance of the extracts of Pistacia lentiscus, P. lentiscus var. chia and P. terebinthus leaves as additives on in vitro release of α-tocopherol. [...] Read more.

α-Tocopherol is the most effective lipid soluble natural antioxidant and free-radical scavenger. The present study aimed to evaluate the performance of the extracts of Pistacia lentiscus, P. lentiscus var. chia and P. terebinthus leaves as additives on in vitro release of α-tocopherol. The α-tocopherol content of Pistacia extracts were determined and the release was investigated from w/o/w multiple emulsion, w/o and o/w simple emulsions through cellulose acetate and cellulose nitrate membranes by using HPLC-UV method. As significant increase in the extent of α-tocopherol release was observed with the addition of Pistacia extracts in all emulsions. They could be suggested as suitable additives in α-tocopherol containing formulations. Full article

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Sci. Pharm., Volume 75, Issue 3 (September 2007) – 3 articles , Pages 97-146

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