Next Article in Journal
Multi-Modal Mass Spectrometric Imaging of Uveal Melanoma
Next Article in Special Issue
Effects of Platycodon grandiflorum on Gut Microbiome and Immune System of Immunosuppressed Mouse
Previous Article in Journal
Unravelling Plant Responses to Stress—The Importance of Targeted and Untargeted Metabolomics
Article

Fiber-Rich Barley Increases Butyric Acid-Producing Bacteria in the Human Gut Microbiota

1
Department of Pediatrics, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan
2
Healthcare New Business Division, TEIJIN Limited, 3-2-1 Kasumigaseki, Tokyo 100-8585, Japan
3
Bio Palette Co., Ltd., 1-1 Rokkodai-cho, Kobe 650-0047, Japan
4
Department of Legal Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Cholsoon Jang
Received: 2 August 2021 / Revised: 17 August 2021 / Accepted: 19 August 2021 / Published: 22 August 2021
(This article belongs to the Special Issue Gut Microbiota Metabolites in Health and Disease)
Butyric acid produced in the intestine by butyric acid-producing bacteria (BAPB) is known to suppress excessive inflammatory response and may prevent chronic disease development. We evaluated whether fiber-rich barley intake increases BAPB in the gut and concomitantly butyric acid in feces. Eighteen healthy adults received granola containing functional barley (BARLEYmax®) once daily for four weeks. Fecal DNA before intake, after intake, and one month after intake was analyzed using 16S rRNA gene sequencing to assess microbial diversity, microbial composition at the order level, and the proportion of BAPB. Fecal butyric acid concentration was also measured. There were no significant differences in diversities and microbial composition between samples. The proportion of BAPB increased significantly after the intake (from 5.9% to 8.2%). However, one month after stopping the intake, the proportion of BAPB returned to the original value (5.4%). Fecal butyric acid concentration increased significantly from 0.99 mg/g feces before intake to 1.43 mg/g after intake (p = 0.028), which decreased significantly to 0.87 mg/g after stopping intake (p = 0.008). As BAPB produce butyric acid by degrading dietary fiber, functional barley may act as a prebiotic, increasing BAPB and consequently butyric acid in the intestine. View Full-Text
Keywords: microbiota; butyric acid-producing bacteria; 16S rRNA gene sequencing; dietary fiber; prebiotics microbiota; butyric acid-producing bacteria; 16S rRNA gene sequencing; dietary fiber; prebiotics
Show Figures

Figure 1

MDPI and ACS Style

Akagawa, S.; Akagawa, Y.; Nakai, Y.; Yamagishi, M.; Yamanouchi, S.; Kimata, T.; Chino, K.; Tamiya, T.; Hashiyada, M.; Akane, A.; Tsuji, S.; Kaneko, K. Fiber-Rich Barley Increases Butyric Acid-Producing Bacteria in the Human Gut Microbiota. Metabolites 2021, 11, 559. https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11080559

AMA Style

Akagawa S, Akagawa Y, Nakai Y, Yamagishi M, Yamanouchi S, Kimata T, Chino K, Tamiya T, Hashiyada M, Akane A, Tsuji S, Kaneko K. Fiber-Rich Barley Increases Butyric Acid-Producing Bacteria in the Human Gut Microbiota. Metabolites. 2021; 11(8):559. https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11080559

Chicago/Turabian Style

Akagawa, Shohei, Yuko Akagawa, Yoko Nakai, Mitsuru Yamagishi, Sohsaku Yamanouchi, Takahisa Kimata, Kazushige Chino, Taiga Tamiya, Masaki Hashiyada, Atsushi Akane, Shoji Tsuji, and Kazunari Kaneko. 2021. "Fiber-Rich Barley Increases Butyric Acid-Producing Bacteria in the Human Gut Microbiota" Metabolites 11, no. 8: 559. https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11080559

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop