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Article

Pterostilbene Enhances Cytotoxicity and Chemosensitivity in Human Pancreatic Cancer Cells

1
Department of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan
2
Department of Forestry, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan
3
Graduate Institute of Food Safety, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 2 April 2020 / Revised: 24 April 2020 / Accepted: 1 May 2020 / Published: 4 May 2020
(This article belongs to the Special Issue Biomolecules and Cancer Prevention)
Gemcitabine (GEM) drug resistance causes high mortality rates and poor outcomes in pancreatic ductal adenocarcinoma (PDAC) patients. Receptor for advanced glycation end products (RAGE) involvement in the GEM resistance process has been demonstrated. Therefore, finding a safe and effective way to inhibit receptors for RAGE-initiated GEM resistance is urgent. Pterostilbene (PTE), a natural methoxylated analogue derived from resveratrol and found in grapes and blueberries, has diverse bioactivities, such as antioxidative, anti-inflammatory, and anticancer qualities. The overall research objective was to determine the potential of PTE to enhance tumor cytotoxicity and chemosensitivity in PDAC cells. Our results have demonstrated that PTE induced S-phase cell cycle arrest, apoptosis, and autophagic cell death and inhibited multidrug resistance protein 1 (MDR1) expression by downregulating RAGE/PI3K/Akt signaling in both MIA PaCa-2 and MIA PaCa-2 GEMR cells (GEM-resistant cells). Remarkably, convincing evidence was established by RAGE small interfering RNA transfection. Taken together, our study demonstrated that PTE promoted chemosensitivity by inhibiting cell proliferation and MDR1 expression via the RAGE/PI3K/Akt axis in PDAC cells. The observations in these experiments indicate that PTE may play a crucial role in MDR1 modulation for PDAC treatment. View Full-Text
Keywords: apoptosis; autophagy; chemosensitivity; gemcitabine; pancreatic ductal adenocarcinoma; pterostilbene; MDR1 apoptosis; autophagy; chemosensitivity; gemcitabine; pancreatic ductal adenocarcinoma; pterostilbene; MDR1
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MDPI and ACS Style

Hsu, Y.-H.; Chen, S.-Y.; Wang, S.-Y.; Lin, J.-A.; Yen, G.-C. Pterostilbene Enhances Cytotoxicity and Chemosensitivity in Human Pancreatic Cancer Cells. Biomolecules 2020, 10, 709. https://0-doi-org.brum.beds.ac.uk/10.3390/biom10050709

AMA Style

Hsu Y-H, Chen S-Y, Wang S-Y, Lin J-A, Yen G-C. Pterostilbene Enhances Cytotoxicity and Chemosensitivity in Human Pancreatic Cancer Cells. Biomolecules. 2020; 10(5):709. https://0-doi-org.brum.beds.ac.uk/10.3390/biom10050709

Chicago/Turabian Style

Hsu, Yi-Hao, Sheng-Yi Chen, Sheng-Yang Wang, Jer-An Lin, and Gow-Chin Yen. 2020. "Pterostilbene Enhances Cytotoxicity and Chemosensitivity in Human Pancreatic Cancer Cells" Biomolecules 10, no. 5: 709. https://0-doi-org.brum.beds.ac.uk/10.3390/biom10050709

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