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Review

The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin

1
Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan
2
Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA
3
Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan
4
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
5
Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan
*
Author to whom correspondence should be addressed.
Received: 23 April 2020 / Revised: 20 May 2020 / Accepted: 21 May 2020 / Published: 29 May 2020
(This article belongs to the Special Issue Biomolecules and Cancer Prevention)
In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurcumin is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo studies have revealed that tetrahydrocurcumin exerts anti-cancer effects through various mechanisms, including modulation of oxidative stress, xenobiotic detoxification, inflammation, proliferation, metastasis, programmed cell death, and immunity. Despite the pharmacological similarities between tetrahydrocurcumin and curcumin, the structure of tetrahydrocurcumin determines its distinct and specific molecular mechanism, thus making it a potential candidate for the prevention and treatment of cancers. However, the utility of tetrahydrocurcumin is yet to be evaluated as only limited pharmacokinetic and oral bioavailability studies have been performed. This review summarizes research on the anti-cancer properties of tetrahydrocurcumin and describes its mechanisms of action. View Full-Text
Keywords: cancer chemoprevention; tetrahydrocurcumin cancer chemoprevention; tetrahydrocurcumin
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MDPI and ACS Style

Lai, C.-S.; Ho, C.-T.; Pan, M.-H. The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin. Biomolecules 2020, 10, 831. https://0-doi-org.brum.beds.ac.uk/10.3390/biom10060831

AMA Style

Lai C-S, Ho C-T, Pan M-H. The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin. Biomolecules. 2020; 10(6):831. https://0-doi-org.brum.beds.ac.uk/10.3390/biom10060831

Chicago/Turabian Style

Lai, Ching-Shu, Chi-Tang Ho, and Min-Hsiung Pan. 2020. "The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin" Biomolecules 10, no. 6: 831. https://0-doi-org.brum.beds.ac.uk/10.3390/biom10060831

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