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Correction published on 12 May 2022, see Biomolecules 2022, 12(5), 693.
Review

PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy

1
Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
2
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Anthony J. Berdis
Received: 28 December 2021 / Revised: 29 January 2022 / Accepted: 2 February 2022 / Published: 3 February 2022 / Corrected: 12 May 2022
(This article belongs to the Collection Feature Papers in Molecular Genetics)
DNA replication can encounter blocking obstacles, leading to replication stress and genome instability. There are several mechanisms for evading this blockade. One mechanism consists of repriming ahead of the obstacles, creating a new starting point; in humans, PrimPol is responsible for carrying out this task. PrimPol is a primase that operates in both the nucleus and mitochondria. In contrast with conventional primases, PrimPol is a DNA primase able to initiate DNA synthesis de novo using deoxynucleotides, discriminating against ribonucleotides. In vitro, PrimPol can act as a DNA primase, elongating primers that PrimPol itself sythesizes, or as translesion synthesis (TLS) DNA polymerase, elongating pre-existing primers across lesions. However, the lack of evidence for PrimPol polymerase activity in vivo suggests that PrimPol only acts as a DNA primase. Here, we provide a comprehensive review of human PrimPol covering its biochemical properties and structure, in vivo function and regulation, and the processes that take place to fill the gap-containing lesion that PrimPol leaves behind. Finally, we explore the available data on human PrimPol expression in different tissues in physiological conditions and its role in cancer. View Full-Text
Keywords: PrimPol; primase; polymerase; repriming; replication stress; genomic instability; cancer PrimPol; primase; polymerase; repriming; replication stress; genomic instability; cancer
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MDPI and ACS Style

Díaz-Talavera, A.; Montero-Conde, C.; Leandro-García, L.J.; Robledo, M. PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy. Biomolecules 2022, 12, 248. https://0-doi-org.brum.beds.ac.uk/10.3390/biom12020248

AMA Style

Díaz-Talavera A, Montero-Conde C, Leandro-García LJ, Robledo M. PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy. Biomolecules. 2022; 12(2):248. https://0-doi-org.brum.beds.ac.uk/10.3390/biom12020248

Chicago/Turabian Style

Díaz-Talavera, Alberto, Cristina Montero-Conde, Luis J. Leandro-García, and Mercedes Robledo. 2022. "PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy" Biomolecules 12, no. 2: 248. https://0-doi-org.brum.beds.ac.uk/10.3390/biom12020248

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