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Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach
Review

Allergen Immunotherapy in Pediatric Asthma: A Pragmatic Point of View

1
Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80100 Naples, Italy
2
Department of Pediatrics, Pediatrics Clinic, Ospedale San Matteo, University of Pavia, 27100 Pavia, Italy
3
Department of Pediatrics, Allergy Center, Istituto G. Gaslini, 16100 Genoa, Italy
4
Allergy Clinic, Casa di Cura Villa Montallegro, 16100 Genoa, Italy
*
Author to whom correspondence should be addressed.
Received: 2 April 2020 / Revised: 18 May 2020 / Accepted: 2 June 2020 / Published: 8 June 2020
(This article belongs to the Special Issue Pediatric Asthma)
To date, the only disease-modifying treatment strategy for allergic rhinitis and asthma is allergen immunotherapy (AIT). There is evidence that AIT improves allergic rhinitis and asthma, such as reducing symptom severity and medication use and improving of quality of life, with a long-lasting effect after the end of the course. The recent clinical trials evidenced AIT effectiveness and safety in allergic asthma. Consequently, the current version of the GINA (Global Initiative for Asthma) guidelines recommend AIT as an add-on therapy for asthma. There is also evidence that AIT may exert preventive activity on the possible progression from allergic rhinitis to asthma in children and the onset of new sensitizations. The present review provides a pragmatic summary of the clinical indications of AIT in pediatric asthma, including the immunological mechanisms, the predictive biomarkers, and the safety issues in clinical practice. View Full-Text
Keywords: allergen-specific immunotherapy; subcutaneous immunotherapy; sublingual immunotherapy; allergic asthma; children allergen-specific immunotherapy; subcutaneous immunotherapy; sublingual immunotherapy; allergic asthma; children
MDPI and ACS Style

Miraglia Del Giudice, M.; Licari, A.; Brambilla, I.; Tosca, M.A.; Ciprandi, G. Allergen Immunotherapy in Pediatric Asthma: A Pragmatic Point of View. Children 2020, 7, 58. https://0-doi-org.brum.beds.ac.uk/10.3390/children7060058

AMA Style

Miraglia Del Giudice M, Licari A, Brambilla I, Tosca MA, Ciprandi G. Allergen Immunotherapy in Pediatric Asthma: A Pragmatic Point of View. Children. 2020; 7(6):58. https://0-doi-org.brum.beds.ac.uk/10.3390/children7060058

Chicago/Turabian Style

Miraglia Del Giudice, Michele, Amelia Licari, Ilaria Brambilla, Maria A. Tosca, and Giorgio Ciprandi. 2020. "Allergen Immunotherapy in Pediatric Asthma: A Pragmatic Point of View" Children 7, no. 6: 58. https://0-doi-org.brum.beds.ac.uk/10.3390/children7060058

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