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Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management

1
Department of Pediatrics, Division of Infectious Diseases, University of California Davis School of Medicine, Sacramento, CA 95817, USA
2
Department of Pediatrics, Division of Allergy, Immunology, and Rheumatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
3
Department of Pediatrics, Division of Neonatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
*
Author to whom correspondence should be addressed.
Received: 30 May 2020 / Revised: 18 June 2020 / Accepted: 19 June 2020 / Published: 1 July 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. Some features of MIS-C resemble Kawasaki Disease, toxic shock syndrome, and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. The relationship of MIS-C to SARS-CoV-2 infection suggests that the pathogenesis involves post-infectious immune dysregulation. Patients with MIS-C should ideally be managed in a pediatric intensive care environment since rapid clinical deterioration may occur. Specific immunomodulatory therapy depends on the clinical presentation. The relationship between the immune response to SARS-CoV-2 vaccines in development and MIS-C requires further study. View Full-Text
Keywords: SARS-CoV-2; COVID-19; multisystem inflammatory syndrome in children (MIS-C); Kawasaki Disease; toxic shock syndrome; hemophagocytic lymphohistiocytosis; macrophage activation syndrome SARS-CoV-2; COVID-19; multisystem inflammatory syndrome in children (MIS-C); Kawasaki Disease; toxic shock syndrome; hemophagocytic lymphohistiocytosis; macrophage activation syndrome
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MDPI and ACS Style

Nakra, N.A.; Blumberg, D.A.; Herrera-Guerra, A.; Lakshminrusimha, S. Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management. Children 2020, 7, 69. https://0-doi-org.brum.beds.ac.uk/10.3390/children7070069

AMA Style

Nakra NA, Blumberg DA, Herrera-Guerra A, Lakshminrusimha S. Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management. Children. 2020; 7(7):69. https://0-doi-org.brum.beds.ac.uk/10.3390/children7070069

Chicago/Turabian Style

Nakra, Natasha A., Dean A. Blumberg, Angel Herrera-Guerra, and Satyan Lakshminrusimha. 2020. "Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management" Children 7, no. 7: 69. https://0-doi-org.brum.beds.ac.uk/10.3390/children7070069

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