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Article

Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls

1
Department of Neonatology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
2
Department of Neonatology, University of Basel Children’s Hospital, 4056 Basel, Switzerland
3
Department of Psychology, University of Basel, 4056 Basel, Switzerland
4
Centre for Early Intervention, Department of Education, 4001 Basel-Stadt, Switzerland
5
Department of Psychology, University of Bielefeld, 33615 Bielefeld, Germany
6
Department of Psychology, University of Warwick, Coventry CV4 7AL, UK
7
Labormedizinische Zentren Dr Risch, 9490 Vaduz, Liechtenstein
8
Department of Pediatric Pharmacology and Pharmacometrics, University of Basel Children’s Hospital, 4056 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Received: 27 August 2020 / Revised: 10 September 2020 / Accepted: 15 September 2020 / Published: 17 September 2020
Background: Preterm infants are at an increased risk of developing hypertension and chronic kidney disease later in life. No recommendations exist for blood pressure (BP) and renal follow up for these patients. Aim: To compare BP and serum and urinary kidney markers between preterm-born adolescents and term-born controls. Methods: BP measurements in 51 preterm-born (≤32 weeks gestational age) and 82 term-born adolescents at the age of 10–15 years were conducted. Stepwise regression analysis explored the association between BP and participant characteristics. Kidney markers measured in the serum and urine were creatinine, neutrophil gelatinase-associated lipocalin (NGAL), and uromodulin. Kidney markers measured in the serum were cystatin C, beta-2 microglobulin, and beta trace protein. Results: Systolic BP was significantly higher in preterm boys compared with term boys, but not in girls, and low birth weight was associated with higher BP in boys. In the preterm group, maternal hypertension/preeclampsia and adolescent height were associated with higher systolic BP. Serum creatinine and NGAL were significantly higher in the preterm group. Conclusions: Our study confirms an inverse sex-dependant relationship between birth weight and BP at adolescent age. The higher serum creatinine and NGAL in the preterm group may indicate that premature birth affects kidney function in the long term. View Full-Text
Keywords: adolescent; follow-up studies; hypertension; kidney; prematurity adolescent; follow-up studies; hypertension; kidney; prematurity
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MDPI and ACS Style

Staub, E.; Urfer-Maurer, N.; Lemola, S.; Risch, L.; Evers, K.S.; Welzel, T.; Pfister, M. Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls. Children 2020, 7, 141. https://0-doi-org.brum.beds.ac.uk/10.3390/children7090141

AMA Style

Staub E, Urfer-Maurer N, Lemola S, Risch L, Evers KS, Welzel T, Pfister M. Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls. Children. 2020; 7(9):141. https://0-doi-org.brum.beds.ac.uk/10.3390/children7090141

Chicago/Turabian Style

Staub, Eveline, Natalie Urfer-Maurer, Sakari Lemola, Lorenz Risch, Katrina S. Evers, Tatjana Welzel, and Marc Pfister. 2020. "Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls" Children 7, no. 9: 141. https://0-doi-org.brum.beds.ac.uk/10.3390/children7090141

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