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Case Report

The Risk of Nonsteroidal Anti-Inflammatory Drugs in Pediatric Medicine: Listen Carefully to Children with Pain

by 1, 1,† and 1,2,*,†
1
Center for Child and Adolescent Medicine, Center for Clinical and Translational Research (CCTR), Helios University Hospital Wuppertal, Witten/Herdecke University, 42283 Wuppertal, Germany
2
Laboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Anna Nilsson
Received: 15 October 2021 / Revised: 5 November 2021 / Accepted: 9 November 2021 / Published: 13 November 2021
(This article belongs to the Special Issue Advances in Pediatric Infection and Immunity)
Over the last decades, the use of over-the-counter analgesics in the general population has increased in Germany. Ibuprofen is one of the most commonly used nonsteroidal anti-inflammatory drug (NSAID) and is frequently prescribed to children as an analgesic and/or antipyretic. Besides having a well-established safety and efficacy profile when used in appropriate doses, cases of NSAID-induced acute kidney injury (AKI) have been described in the pediatric population, particularly in the context of dehydration and in combination with other drugs. The ingestion of more than 400 mg/kg is associated with severe or life-threatening toxicity. This report is about two previously healthy adolescents, who developed AKI after taking high daily dose of ibuprofen as a pain reliever without any appropriate medical supervision. With these case reports, in addition to the side effect profiles of this analgesic, we would also like to present a certain therapeutic recommendation that we applied in these patients, and furthermore appeal to pediatricians to strictly set the indications for ibuprofen intake. View Full-Text
Keywords: ibuprofen; nonsteroidal anti-inflammatory drugs; acute kidney injury; pediatric ibuprofen; nonsteroidal anti-inflammatory drugs; acute kidney injury; pediatric
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MDPI and ACS Style

Mboma, O.; Wirth, S.; Aydin, M. The Risk of Nonsteroidal Anti-Inflammatory Drugs in Pediatric Medicine: Listen Carefully to Children with Pain. Children 2021, 8, 1048. https://0-doi-org.brum.beds.ac.uk/10.3390/children8111048

AMA Style

Mboma O, Wirth S, Aydin M. The Risk of Nonsteroidal Anti-Inflammatory Drugs in Pediatric Medicine: Listen Carefully to Children with Pain. Children. 2021; 8(11):1048. https://0-doi-org.brum.beds.ac.uk/10.3390/children8111048

Chicago/Turabian Style

Mboma, Olivier, Stefan Wirth, and Malik Aydin. 2021. "The Risk of Nonsteroidal Anti-Inflammatory Drugs in Pediatric Medicine: Listen Carefully to Children with Pain" Children 8, no. 11: 1048. https://0-doi-org.brum.beds.ac.uk/10.3390/children8111048

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