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Respiratory Distress in the Newborn with Primary Ciliary Dyskinesia

Section of Pediatric Pulmonology, Allergy and Sleep Medicine, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN 46202, USA
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Author to whom correspondence should be addressed.
Academic Editors: Roberto W. Dal Negro and Rita Marie Ryan
Received: 29 December 2020 / Revised: 8 February 2021 / Accepted: 10 February 2021 / Published: 18 February 2021
(This article belongs to the Special Issue Neonatal Respiratory Distress)
Primary ciliary dyskinesia (PCD) is inherited in a predominantly autosomal recessive manner with over 45 currently identified causative genes. It is a clinically heterogeneous disorder that results in a chronic wet cough and drainage from the paranasal sinuses, chronic otitis media with hearing impairment as well as male infertility. Approximately 50% of patients have situs inversus totalis. Prior to the development of chronic oto-sino-pulmonary symptoms, neonatal respiratory distress occurs in more than 80% of patients as a result of impaired mucociliary clearance and mucus impaction causing atelectasis and lobar collapse. Diagnosis is often delayed due to overlapping symptoms with other causes of neonatal respiratory distress. A work up for PCD should be initiated in the newborn with compatible clinical features, especially those with respiratory distress, consistent radiographic findings or persistent oxygen requirement and/or organ laterality defects View Full-Text
Keywords: primary ciliary dyskinesia; neonatal respiratory distress primary ciliary dyskinesia; neonatal respiratory distress
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MDPI and ACS Style

Machogu, E.; Gaston, B. Respiratory Distress in the Newborn with Primary Ciliary Dyskinesia. Children 2021, 8, 153. https://0-doi-org.brum.beds.ac.uk/10.3390/children8020153

AMA Style

Machogu E, Gaston B. Respiratory Distress in the Newborn with Primary Ciliary Dyskinesia. Children. 2021; 8(2):153. https://0-doi-org.brum.beds.ac.uk/10.3390/children8020153

Chicago/Turabian Style

Machogu, Evans, and Benjamin Gaston. 2021. "Respiratory Distress in the Newborn with Primary Ciliary Dyskinesia" Children 8, no. 2: 153. https://0-doi-org.brum.beds.ac.uk/10.3390/children8020153

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