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Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome

Department of Pediatrics, Case Western Reserve University, UH Rainbow Babies & Children’s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USA
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Author to whom correspondence should be addressed.
Academic Editor: Steven M. Donn
Received: 16 February 2021 / Revised: 4 March 2021 / Accepted: 19 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue Neonatal Respiratory Distress)
Infants born through meconium-stained amniotic fluid (MSAF) are 100 times more likely than infants born through clear amniotic fluid to develop respiratory distress in the neonatal period. Meconium aspiration syndrome (MAS) is a common cause of respiratory distress in term and post-mature neonates. MAS is defined as respiratory distress accompanied by a supplemental oxygen requirement in an infant born with MSAF, in the absence of any other identified etiology to explain the symptoms. Therapy for MAS is supportive, and should be tailored to each infant’s specific pathophysiology. In cases of MAS with severe persistent pulmonary hypertension of the newborn (PPHN), patients may remain hypoxic despite aggressive ventilation, and in these cases surfactant, inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO) can be life-saving. Long-term prognosis for MAS is more related to severity of initial hypoxemia and possible neurological insult than to the pulmonary pathology. View Full-Text
Keywords: meconium aspiration syndrome; respiratory distress; surfactant meconium aspiration syndrome; respiratory distress; surfactant
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MDPI and ACS Style

Olicker, A.L.; Raffay, T.M.; Ryan, R.M. Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome. Children 2021, 8, 246. https://0-doi-org.brum.beds.ac.uk/10.3390/children8030246

AMA Style

Olicker AL, Raffay TM, Ryan RM. Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome. Children. 2021; 8(3):246. https://0-doi-org.brum.beds.ac.uk/10.3390/children8030246

Chicago/Turabian Style

Olicker, Arielle L., Thomas M. Raffay, and Rita M. Ryan 2021. "Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome" Children 8, no. 3: 246. https://0-doi-org.brum.beds.ac.uk/10.3390/children8030246

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