Effects on Recovery of Pediatric Patients Undergoing Total Intravenous Anesthesia with Propofol versus Ketofol for Short—Lasting Laparoscopic Procedures
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Intraoperative Monitoring
2.3. Study Design
2.4. Outcomes of the Study
2.5. Sample Size Calculation
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group I | Group II | p | |
---|---|---|---|
Propofol (n = 100) | Ketofol (n = 100) | ||
Demographic characteristics of patients | |||
Age (years) median (IQR) | 5 (3, 5) | 5 (3, 5.5) | 0.144 * |
Gender, n (%) Male Female | 75 (75) 25 (25) | 77 (77) 23 (23) | 0.740 † |
Weight (g) median (IQR) | 20 (14.5, 29) | 19.5 (13, 27) | 0.139 * |
Hemodynamic characteristics of patients, median (IQR) | |||
Systolic blood pressure (mmHg) | 117 (110, 124) | 119 (108, 123) | 0.530 * |
Diastolic arterial pressure (mmHg) | 71 (66, 76) | 69 (64, 76) | 0.365 * |
Heart rate (bpm) | 128 (100, 147) | 126 (103, 146) | 0.235 * |
Group I | Group II | p | |
---|---|---|---|
Propofol (n = 100) | Ketofol (n = 100) | ||
Sefofluran (for iv. canula), n (%) | 57 (57) | 64 (64) | 0.311 * |
Length of iv infusion (min) median (IQR) | 24.5 (19, 30) | 23 (16, 30) | 0.371 † |
Duration of anesthesia (min) median (IQR) | 60 (50, 65) | 47 (40, 57) | <0.00001 † |
Extubation time (s) median (IQR) | 530 (410, 600) | 240 (120, 330) | <0.00001 † |
Fentanyl (μg/kg) median (IQR) | 4 (3, 5) | 2 (1, 2) | <0.00001 † |
Fentanyl—TOTAL (μg) median (IQR) | 100 (80, 125) | 50 (40, 60) | <0.00001 † |
Propofol (mg/kg) median (IQR) | 13 (9, 15) | 5.8 (4, 7.5) | <0.00001 † |
Propofol—TOTAL (mg) median (IQR) | 260 (200, 350) | 160 (120, 210) | <0.00001 † |
Group I | Group II | p | |
---|---|---|---|
Propofol | Ketofol | ||
(n = 100) | (n = 100) | ||
SpO2 PACU—at arrival median (IQR) | 93 (92, 94.5) | 99 (98, 99) | <0.00001 * |
SpO2 PACU—after 30 min median (IQR) | 98 (97, 99) | 99 (98, 100) | <0.00001 * |
Length of stay in PACU (min) median (IQR) | 100 (90, 110) | 35 (30, 35) | <0.00001 * |
Number of patients requiring oxygen in PACU, n (%) | 56 (56%) | 0 (0%) | <0.00001 † |
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Biliškov, A.N.; Ivančev, B.; Pogorelić, Z. Effects on Recovery of Pediatric Patients Undergoing Total Intravenous Anesthesia with Propofol versus Ketofol for Short—Lasting Laparoscopic Procedures. Children 2021, 8, 610. https://0-doi-org.brum.beds.ac.uk/10.3390/children8070610
Biliškov AN, Ivančev B, Pogorelić Z. Effects on Recovery of Pediatric Patients Undergoing Total Intravenous Anesthesia with Propofol versus Ketofol for Short—Lasting Laparoscopic Procedures. Children. 2021; 8(7):610. https://0-doi-org.brum.beds.ac.uk/10.3390/children8070610
Chicago/Turabian StyleBiliškov, Ana Nevešćanin, Božena Ivančev, and Zenon Pogorelić. 2021. "Effects on Recovery of Pediatric Patients Undergoing Total Intravenous Anesthesia with Propofol versus Ketofol for Short—Lasting Laparoscopic Procedures" Children 8, no. 7: 610. https://0-doi-org.brum.beds.ac.uk/10.3390/children8070610