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Article

Dynamic Model for Biomass and Proteins Production by Three Bacillus Thuringiensis ssp Kurstaki Strains

1
Toulouse Biotechnology Institute, Bio & Chemical Engineering, Université de Toulouse, F-31077 Toulouse, France
2
Laboratoires Pharmaceutiques MédiS, B.P 206 Nabeul 8000, Tunisia
3
Centre of Biotechnology of Sfax, B.P 1177 Sfax 3018, Tunisia
4
Faculty of Sciences, Saint-Joseph University, Riad El Solh, Beirut 1004 2020, Lebanon
5
Toulouse White Biotechnology (UMS INRAE/INSA/CNRS), 135 Avenue de Rangueil, F-31077 Toulouse, France
*
Author to whom correspondence should be addressed.
Academic Editor: Philippe Bogaerts
Received: 27 October 2021 / Revised: 23 November 2021 / Accepted: 24 November 2021 / Published: 28 November 2021
(This article belongs to the Special Issue Mathematical Modeling and Control of Bioprocesses)
Bacillus thuringiensis is a microorganism used for the production of biopesticides worldwide. In the present paper, different kinetic models were analyzed to study and compare three different strains of Bt ssp kurstaki (LIP, BLB1, and HD1). Bioperformances (vegetative cell, spore, substrate, and protein) and successive culture phases (oxidative growth, limitation and sporulation, and protein release) were depicted with an overarching aim to estimate total protein productivity, yield, and titer. In the end, two models were calibrated using experimental dataset (11 batches culture in 3 L bioreactor with semisynthetic medium), subsequently validated, and statistically compared. Both models satisfactorily followed the dynamics of the experimental data. Finally, a dynamic model was selected following the Akaike information criterion (AIC). View Full-Text
Keywords: B. thuringiensis kurstaki; biopesticides; kinetic parameters; dynamic model B. thuringiensis kurstaki; biopesticides; kinetic parameters; dynamic model
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MDPI and ACS Style

Monroy, T.S.; Abdelmalek, N.; Rouis, S.; Kallassy, M.; Saad, J.; Abboud, J.; Cescut, J.; Bensaid, N.; Fillaudeau, L.; Aceves-Lara, C.A. Dynamic Model for Biomass and Proteins Production by Three Bacillus Thuringiensis ssp Kurstaki Strains. Processes 2021, 9, 2147. https://0-doi-org.brum.beds.ac.uk/10.3390/pr9122147

AMA Style

Monroy TS, Abdelmalek N, Rouis S, Kallassy M, Saad J, Abboud J, Cescut J, Bensaid N, Fillaudeau L, Aceves-Lara CA. Dynamic Model for Biomass and Proteins Production by Three Bacillus Thuringiensis ssp Kurstaki Strains. Processes. 2021; 9(12):2147. https://0-doi-org.brum.beds.ac.uk/10.3390/pr9122147

Chicago/Turabian Style

Monroy, Tatiana S., Nouha Abdelmalek, Souad Rouis, Mireille Kallassy, Jihane Saad, Joanna Abboud, Julien Cescut, Nadia Bensaid, Luc Fillaudeau, and César A. Aceves-Lara. 2021. "Dynamic Model for Biomass and Proteins Production by Three Bacillus Thuringiensis ssp Kurstaki Strains" Processes 9, no. 12: 2147. https://0-doi-org.brum.beds.ac.uk/10.3390/pr9122147

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