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Open AccessCase Report

Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic

Department of Dermatology, Medical Faculty Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany
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Received: 13 October 2020 / Revised: 27 November 2020 / Accepted: 2 December 2020 / Published: 4 December 2020
(This article belongs to the Section Clinico-Pathological Correlation in Dermatopathology)
Contemporarily to the new SARS-CoV-2 mediated COVID-19 pandemic, a rise in patients with acral chilblain lesions has been described. They manifest late after mild disease or asymptomatic exposure to SARS-CoV-2. Their pathogenic evolution is currently unknown. In biopsies from three patients with acral partially ulcerating chilblain lesions that occurred associated to the COVID-19 pandemic, we analysed the expression of type I interferon induced proteins and signal transduction kinases. Histology demonstrated perivascular and periadnexal lymphohistiocytic infiltrates and endothelial dominated MxA-staining, as well as pJAK1 activation. Our findings demonstrate induction of the type I IFN pathway in lesional sections of COVID-19-associated chilblain-like lesions. This may indicate a local antiviral immune activation status associated with preceding exposure to SARS-CoV-2. View Full-Text
Keywords: SARS-CoV-2; chilblain; type I interferon SARS-CoV-2; chilblain; type I interferon
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MDPI and ACS Style

Aschoff, R.; Zimmermann, N.; Beissert, S.; Günther, C. Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic. Dermatopathology 2020, 7, 57-63. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology7030010

AMA Style

Aschoff R, Zimmermann N, Beissert S, Günther C. Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic. Dermatopathology. 2020; 7(3):57-63. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology7030010

Chicago/Turabian Style

Aschoff, Roland; Zimmermann, Nick; Beissert, Stefan; Günther, Claudia. 2020. "Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic" Dermatopathology 7, no. 3: 57-63. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology7030010

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