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Pleomorphic Hyalinizing Angiectatic Tumor (PHAT): Review of the Literature with Case Presentation

Department of Emergency and Organ Transplantation—Section of Pathology, University of Bari Aldo Moro, 70124 Bari, Italy
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Academic Editor: Gürkan Kaya
Received: 5 March 2021 / Revised: 30 March 2021 / Accepted: 2 April 2021 / Published: 4 April 2021
Pleomorphic hyalinizing angiectatic tumor (PHAT) is a very rare entity of soft tissue considered a “neoplasm of uncertain behaviour of connective or other soft tissue” by the World Health Organization (2020). It develops in subcutaneous tissue of the lower extremities, more frequently in the region of the ankle and foot, and rarely as a deep-seated soft tissue mass in locations such as the perineum, buttock, arms, head and neck, and viscera. Although inconsistent cytogenetic data have been reported on PHAT so far, there are potential morphological and genetic overlaps with hemosiderotic fibrolipomatous tumor (HFLT) and myxoinflammatory fibroblastic sarcoma (MIFS). Here we report a case of PHAT at the level of the upper third of the right thigh in a 48-year-old patient and we also focus on the differential diagnoses of these entities and conduct a literature review of reported cases. View Full-Text
Keywords: soft tissue; PHAT; immunohistochemistry soft tissue; PHAT; immunohistochemistry
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MDPI and ACS Style

Cazzato, G.; Colagrande, A.; Cimmino, A.; Lettini, T.; Savino, M.T.; Martella, C.; Ingravallo, G.; Resta, L. Pleomorphic Hyalinizing Angiectatic Tumor (PHAT): Review of the Literature with Case Presentation. Dermatopathology 2021, 8, 97-102. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020015

AMA Style

Cazzato G, Colagrande A, Cimmino A, Lettini T, Savino MT, Martella C, Ingravallo G, Resta L. Pleomorphic Hyalinizing Angiectatic Tumor (PHAT): Review of the Literature with Case Presentation. Dermatopathology. 2021; 8(2):97-102. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020015

Chicago/Turabian Style

Cazzato, Gerardo, Anna Colagrande, Antonietta Cimmino, Teresa Lettini, Maria T. Savino, Carmen Martella, Giuseppe Ingravallo, and Leonardo Resta. 2021. "Pleomorphic Hyalinizing Angiectatic Tumor (PHAT): Review of the Literature with Case Presentation" Dermatopathology 8, no. 2: 97-102. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020015

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